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NCT03884049: NEO
Neovascularization Embolisation for Knee Osteoarthritis.(NEO)
NA trial testing Embolization in Osteoarthritis, Knee in 58 participants. Completed in 30 January 2023.
5 May 2022
Quick facts
| Lead sponsor | Erasmus Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 58 |
| Start date | 5 June 2019 |
| Primary completion | 5 May 2022 |
| Estimated completion | 30 January 2023 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Embolization
- Sham embolization
Conditions studied
- Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →
Sponsor
Erasmus Medical Center
Who can join
18 and older, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this double blind randomized sham controlled study the investigators want to establish the efficacy of transcatheter arterial embolization of neovessels for patients with symptomatic mild to moderate knee osteoarthritis after 4 months compared to a sham-embolization.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Genicular artery embolisation versus sham embolisation for symptomatic osteoarthritis of the knee: a randomised controlled trial.
van Zadelhoff TA, Bos PK, Moelker A, Bierma-Zeinstra SMA, et al · · 2024 · cited 18× · PMID 39353688 · DOI 10.1136/bmjopen-2024-087047 -
Genicular artery embolization as a novel treatment for mild to moderate knee osteoarthritis: protocol design of a randomized sham-controlled clinical trial.
van Zadelhoff TA, Moelker A, Bierma-Zeinstra SMA, Bos PK, et al · · 2022 · cited 10× · PMID 34998425 · DOI 10.1186/s13063-021-05942-x -
Genicular artery embolization for knee osteoarthritis: A systematic review of sham-controlled randomized trials.
Milhem F, Takhman M, Elgendy MS, Zahra AA, et al · · 2025 · PMID 40766107 · DOI 10.1016/j.jor.2025.07.022
Verify or expand the search:
- PubMed search for NCT03884049
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT05714124 — Liver Embolization Approaches for Tumor Management · recruiting
- NCT03853434 — Efficacy of Angiographic Embolization vs Non-embolization of Moderate/Poor Vascularized Vertebral Metastases on Intraope · NA · recruiting
Other recruiting trials for Osteoarthritis, Knee
Currently open trials in the same condition.
- NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
- NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
- NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
- NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
- NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting
Other Erasmus Medical Center trials
Trials by the same sponsor.
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- NCT07402109 — CBCT Guided Markerless SBRT for Renal Cell Cancer · NA · recruiting
- NCT07383194 — Prediction Models for LDLT Outcomes · not yet recruiting
- NCT07426575 — Evaluating the Usability of New Dialysis Bags · not yet recruiting
- NCT07329296 — The Regenerative Capacity of the Donor Liver After Living Donor Liver Transplantation: an Ambidirectional Cohort Study · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03884049 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Erasmus Medical Center
- Last refreshed: 1 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03884049.
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