NCT03883711: AMIPE

Acute Myocardial Infarction: Prognostic and Therapeutic Evaluation

Recruiting now Last updated 30 January 2026

What this trial tests

trial testing Database in Acute Coronary Syndrome in 11,000 participants. Currently enrolling.

Timeline

1 January 2017

Primary endpoint
31 December 2024

31 December 2028

Quick facts

Lead sponsor	IRCCS Azienda Ospedaliero-Universitaria di Bologna
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	11,000
Start date	1 January 2017
Primary completion	31 December 2024
Estimated completion	31 December 2028
Sites	3 locations across Italy

Drugs / interventions tested

• Database

Conditions studied

• Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →
• Myocardium; Injury — all drugs for Myocardium; Injury →

Sponsor

IRCCS Azienda Ospedaliero-Universitaria di Bologna — full company profile →

Who can join

18 and older, any sex, with Acute Coronary Syndrome or Myocardium; Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

AMIPE is both a retrospective and prospective study which was designed in order to collect data of patients with acute coronary syndromes and myocardial injury and to improve the knowledge about these conditions.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Hyperglycemia, inflammatory response and infarct size in obstructive acute myocardial infarction and MINOCA.
   Paolisso P, Foà A, Bergamaschi L, Donati F, et al · · 2021 · cited 94× · PMID 33530978 · DOI 10.1186/s12933-021-01222-9
2. Impact of admission hyperglycemia on short and long-term prognosis in acute myocardial infarction: MINOCA versus MIOCA.
   Paolisso P, Foà A, Bergamaschi L, Angeli F, et al · · 2021 · cited 72× · PMID 34560876 · DOI 10.1186/s12933-021-01384-6
3. Secondary Prevention Medical Therapy and Outcomes in Patients With Myocardial Infarction With Non-Obstructive Coronary Artery Disease.
   Paolisso P, Bergamaschi L, Saturi G, D'Angelo EC, et al · · 2019 · cited 58× · PMID 32082147 · DOI 10.3389/fphar.2019.01606
4. Prognostic Relevance of Type 4a Myocardial Infarction and Periprocedural Myocardial Injury in Patients With Non-ST-Segment-Elevation Myocardial Infarction.
   Armillotta M, Bergamaschi L, Paolisso P, Belmonte M, et al · · 2025 · cited 48× · PMID 39968630 · DOI 10.1161/circulationaha.124.070729
5. Sex- and age-related differences in outcomes of patients with acute myocardial infarction: MINOCA vs. MIOCA.
   Canton L, Fedele D, Bergamaschi L, Foà A, et al · · 2023 · cited 28× · PMID 37261384 · DOI 10.1093/ehjacc/zuad059
6. Performance of Prognostic Scoring Systems in MINOCA: A Comparison among GRACE, TIMI, HEART, and ACEF Scores.
   Fedele D, Canton L, Bodega F, Suma N, et al · · 2023 · cited 8× · PMID 37685754 · DOI 10.3390/jcm12175687
7. Impact of glucometabolic status on type 4a myocardial infarction in patients with non-ST-segment elevation myocardial infarction: the role of stress hyperglycemia ratio.
   Armillotta M, Bergamaschi L, Angeli F, Belmonte M, et al · · 2025 · cited 3× · PMID 41076534 · DOI 10.1186/s12933-025-02837-y
8. Identification of Clinical Phenotypes in Type 2 Myocardial Infarction: Insights Into Characteristics, Prognosis, and Management Strategies.
   Bertolini D, Armillotta M, Angeli F, Sansonetti A, et al · · 2025 · cited 2× · PMID 40886105 · DOI 10.1161/jaha.125.042858