NCT03881865

P25/30 SSEPs and Neurological Prognosis After Cardiac Arrest

Completed Last updated 6 May 2023

What this trial tests

trial in Out-Of-Hospital Cardiac Arrest in 93 participants. Completed in 6 October 2021.

Timeline

8 October 2018

Primary endpoint
6 October 2021

6 October 2021

Quick facts

Lead sponsor	University Hospital Plymouth NHS Trust
Status	Completed
Study type	OBSERVATIONAL
Enrollment	93
Start date	8 October 2018
Primary completion	6 October 2021
Estimated completion	6 October 2021
Sites	1 location across United Kingdom

Conditions studied

• Out-Of-Hospital Cardiac Arrest — all drugs for Out-Of-Hospital Cardiac Arrest →

Sponsor

University Hospital Plymouth NHS Trust

Who can join

18 and older, any sex, with Out-Of-Hospital Cardiac Arrest. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Study Title:

Early recorded P25/30 somatosensory evoked potentials are associated with neurologic prognosis of comatose survivors after out of hospital cardiac arrest.

Design:

Prospective, observational, non-interventional, study - prospective collection of data and interpretation. Analysis of the data and assessment of prognostic value of the P25/30 in critically ill patients post cardiac arrest.

Study Aims:

To be the first attempt to validate the prognostic potential of early recording \[between 24-36 hours post Return Of Spontaneous Circulation\] of P25/30 potentials in comatose survivors who are admitted to a British Intensive care unit after out of hospital cardiac arrest and who are not treated by hypothermic targeted temperature management.

\[Validation of the prognostication significance of P25/30 Somatosensory Evoked Potentials in predicting neurologic outcome in comatose survivors post out of hospital cardiac arrest\].

Outcome Measures:

Primary Endpoint: Neurologic outcome assessed by Cerebral Performance Category score at hospital discharge.

Secondary endpoints: Mortality at hospital discharge and 28 days \[which occurs first\], comparison of prognostic benefit of N20 and P25/30 based multimodal prognostic models.

Population:

Comatose survivors, after out of hospital cardiac arrest, treated in Derriford Hospital ICU, Penrose and Pencarrow wards.

Eligibility:

Adults \[\>18 years old\], out of hospital cardiac arrest, comatose after Return Of Spontaneous Circulation, admission to intensive care Estimated Duration:36 months

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.