NCT03881020 is a Phase 4 clinical trial of Silver diamine Fluoride 38% in Dental Caries, sponsored by Ain Shams University.

Who is sponsoring NCT03881020?

NCT03881020 is sponsored by Ain Shams University.

What drugs are being tested in NCT03881020?

Interventions in NCT03881020: Silver diamine Fluoride 38%, Conventional atraumatic restorative treatment.

What condition does NCT03881020 study?

NCT03881020 studies Dental Caries.

Is NCT03881020 still recruiting?

NCT03881020 is currently completed. Last updated 23 February 2022.

Last reviewed 2022-02-23 · How we verify

NCT03881020

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Silver Modified and Conventional Atraumatic Restorative Treatment Modalities

Completed Phase 4 Last updated 23 February 2022

What this trial tests

Phase 4 trial testing Silver diamine Fluoride 38% in Dental Caries in 100 participants. Completed in 30 December 2021.

Timeline

3 August 2020

Primary endpoint
3 November 2021

30 December 2021

Quick facts

Lead sponsor	Ain Shams University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	100
Start date	3 August 2020
Primary completion	3 November 2021
Estimated completion	30 December 2021
Sites	1 location across Egypt

Drugs / interventions tested

Silver diamine Fluoride 38% — full drug profile →
Conventional atraumatic restorative treatment

Conditions studied

Dental Caries — all drugs for Dental Caries →

Sponsor

Ain Shams University

Who can join

Adults 5 to 9, any sex, with Dental Caries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study is a randomized controlled trial aiming to compare the effectiveness of Silver modified atraumatic restorative technique and (SMART) and conventional atraumatic restorative technique (ART) regarding their caries arresting properties in primary molars, patient acceptance and cost effectiveness.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Survival Analysis and Cost Effectiveness of Silver Modified Atraumatic Restorative Treatment (SMART) and ART Occlusal Restorations in Primary Molars: a randomized controlled trial.
Aly AAM, Aziz AMA, Elghazawy RK, El Fadl RKA. · · 2023 · cited 18× · PMID 36460236 · DOI 10.1016/j.jdent.2022.104379

Verify or expand the search:

Other trials of Silver diamine Fluoride 38%

Trials testing the same drug.

NCT07194629 — Pilot and Feasibility Study of Impact of SDF 38% Application on Oral Health of Elderly With Autonomy Loss · Phase 4 · not yet recruiting
NCT07447583 — Traditional vs. Minimally Invasive Decay Treatments in Primary Molars: An 18-month Split-mouth Randomized Study · NA · completed
NCT06699199 — Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient · Phase 4 · recruiting

Other recruiting trials for Dental Caries

Currently open trials in the same condition.

NCT06787261 — Involvement of Archaea in Carious Disease · NA · recruiting
NCT06753669 — Mothers' Action Project for Child Health · NA · recruiting
NCT07431463 — Effects of Different Remineralization Agents on the Progression of Non-Cavitated Approximal Carious Lesions in Primary T · NA · active not recruiting
NCT07134114 — Occlusal Impact of Hall Crowns in Primary Molars · NA · recruiting
NCT07181967 — SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in Children · NA · recruiting

Other Ain Shams University trials

Trials by the same sponsor.

NCT07435493 — Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstru · NA · not yet recruiting
NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
NCT07531030 — Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blo · NA · not yet recruiting
NCT06839027 — Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass · not yet recruiting
NCT07516535 — DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03881020 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
Last refreshed: 23 February 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03881020.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing