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NCT03879265
Validation of a NICS Method Using the Culture Medium
trial testing Noninvasive chromosome screening in Chromosome Abnormality in 50 participants. Completed in 20 January 2020.
1 December 2019
Quick facts
| Lead sponsor | Instituto Bernabeu |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 1 February 2019 |
| Primary completion | 1 December 2019 |
| Estimated completion | 20 January 2020 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Noninvasive chromosome screening
Conditions studied
- Chromosome Abnormality — all drugs for Chromosome Abnormality →
- Abnormality — all drugs for Abnormality →
Sponsor
Instituto Bernabeu — full company profile →
Who can join
Adults 19 to 49, male only, with Chromosome Abnormality or Abnormality. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to validate a non-invasive method of chromosomal screening (NICS), based on the Multiple Annealing and Looping Based Amplification Cycles- Next-generation Sequencing (MALBAC-NGS) technology, in order to determine the chromosomal endowment of a blastocyst from the DNA of the embryonic culture medium. The chromosomal status of the embryo from an embryo biopsy of trophoectoderm will be established (usual clinical practice), the chromosomal endowment from the DNA of the embryonic culture medium will be determined, and the results using the NICS and the conventional invasive method (Preimplantation Genetic Testing for Aneuploidy \[PGT-A\]) will be compared.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Preimplantation Genetic Testing for Chromosomal Abnormalities: Aneuploidy, Mosaicism, and Structural Rearrangements.
Viotti M. · · 2020 · cited 112× · PMID 32485954 · DOI 10.3390/genes11060602
Verify or expand the search:
- PubMed search for NCT03879265
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Instituto Bernabeu trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03879265 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Instituto Bernabeu
- Last refreshed: 10 August 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03879265.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing