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NCT03879252: UP-TIP
Tolerance of Teeth Brushing During Prolonged Aplasia
Phase 3 trial testing Toothbrush in Aplasia in 76 participants. Completed in 1 February 2023.
1 February 2023
Quick facts
| Lead sponsor | University Hospital, Angers |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 76 |
| Start date | 22 July 2019 |
| Primary completion | 1 February 2023 |
| Estimated completion | 1 February 2023 |
| Sites | 1 location across France |
Drugs / interventions tested
- Toothbrush
- Mouthwashes — full drug profile →
Conditions studied
- Aplasia — all drugs for Aplasia →
Sponsor
University Hospital, Angers
Who can join
18 and older, any sex, with Aplasia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
It is currently not allowed for patients with prolonged aplasia, following intensive chemotherapy, to brush teeth due to the risk of damaging the oral mucosa with risk of haemorrhage and infectious entrance door. Mouthwash is currently prescribed to prevent these complications. Many patients, however, ask to brush their teeth for greater comfort and a feeling of well-being. Some haematology services allow tooth brushing while others prohibit tooth brushing without study. Investigators wanted to conduct a study to assess the feasibility, the safety of tooth brushing for aplastic patient comfort, hemopathy and/or chemotherapies causing mucous membrane alteration that increases infectious risk and the risk of gingivorragia.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03879252
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Toothbrush
Trials testing the same drug.
- NCT07134231 — Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model · Phase 3 · completed
- NCT07409610 — Miswak (Salvadora Persica) Versus a Toothbrush in Plaque Removal · NA · completed
- NCT07029438 — Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis · Phase 4 · completed
- NCT06732466 — Evaluation of the Effect of a Toothpaste Containing 0.3% Chlorhexidine in Subjects With Established Dental Plaque and Gi · Phase 3 · completed
- NCT06732518 — Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralizati · Phase 3 · completed
Other recruiting trials for Aplasia
Currently open trials in the same condition.
- NCT05790733 — HYPNONAG : Therapeutic Communication Versus Traditional Method for Naso-gastric Intubation in Haematology · NA · recruiting
Other University Hospital, Angers trials
Trials by the same sponsor.
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- NCT07468565 — Surgical Approach for the Treatment of Hirschsprung Disease Using the Swenson Technique (SMILES) · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03879252 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Angers
- Last refreshed: 30 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03879252.
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