NCT03876652 is a NA clinical trial of Pacemaker with Closed Loop Stimulation (CLS) in Syncope, sponsored by CES University.

Who is sponsoring NCT03876652?

NCT03876652 is sponsored by CES University.

What drugs are being tested in NCT03876652?

Interventions in NCT03876652: Pacemaker with Closed Loop Stimulation (CLS).

Is NCT03876652 still recruiting?

NCT03876652 is currently completed. Last updated 9 March 2022.

Last reviewed 2022-03-09 · How we verify

NCT03876652

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pacemaker Effect With Closed Loop Sensor in Neuromodulated Syncope Refractory to Medical Therapy

Completed NA Last updated 9 March 2022

What this trial tests

NA trial testing Pacemaker with Closed Loop Stimulation (CLS) in Syncope in 48 participants. Completed in 1 March 2022.

Timeline

22 November 2017

Primary endpoint
15 April 2021

1 March 2022

Quick facts

Lead sponsor	CES University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	48
Start date	22 November 2017
Primary completion	15 April 2021
Estimated completion	1 March 2022
Sites	2 locations across Colombia

Drugs / interventions tested

Pacemaker with Closed Loop Stimulation (CLS)

Conditions studied

Syncope — all drugs for Syncope →

Sponsor

CES University

Who can join

18 and older, any sex, with Syncope. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Vasovagal syncope is an entity frequently in the emergency services, its treatment includes pharmacological and non-pharmacological measures, and in some severe cases, requires the implantation of cardiac stimulation devices, specifically, those pacemakers that have closed-loop sensors (CLS). This research is an intervention study, multi-institutional, randomized and double blind that will be carried out in patients older than 18 years, with a diagnosis of neurally mediated type 1, 2A or 2B syncope documented in a tilting table test, who have had at least 2 syncope in the last year and that significantly affects the quality of life despite the use of pharmacological and non-pharmacological non-interventionist therapy. This study aims to evaluate the effect of cardiac pacing therapy with CLS pacemakers on quality of life, recurrence of syncope and pre-syncopal symptoms in patients with a diagnosis of neurally mediated syncope in this group of patients.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Syncope

Currently open trials in the same condition.

NCT05896592 — Comparison of the Efficacy and Safety of Cardioneuroablation to Permanent Pacing in Patients With an Implanted Pacemaker · NA · recruiting
NCT06526884 — Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC) · NA · active not recruiting
NCT06503653 — Creation of a Syncope Channel for Patients Admitted to the Emergency Department for Loss of Consciousness and Not Hospit · NA · active not recruiting
NCT06288633 — Cardioneuroablation for Bradyarrhythmia · NA · recruiting
NCT06087497 — The Z Stitch Early Bed Rest Assessment Study · NA · recruiting

Other CES University trials

Trials by the same sponsor.

NCT06986343 — Impact of Palatal Expansion and Up-Locker Activator on Sleep and Pharyngeal Dimensions in Children · NA · enrolling by invitation
NCT05923723 — Efficacy of a Dietary Intervention for the Treatment of Constipation in Institutionalized Older Adults. Medellín, 2023-2 · NA · completed
NCT05310162 — Effect of the Intervention "Food, Fun and Family" on Sleep Bruxism in Children · NA · unknown
NCT04602507 — Ivermectin in Adults With Severe COVID-19. · Phase 2 · terminated
NCT03950700 — Bupivacaine in the Treatment of Postoperative Pain of Impacted Third Molar Extraction · Phase 4 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03876652 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by CES University
Last refreshed: 9 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03876652.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing