NCT03875326 (STIM) is a NA clinical trial of 1 mA HD-tDCS in Mild Cognitive Impairment, sponsored by University of Michigan.

Who is sponsoring NCT03875326?

NCT03875326 is sponsored by University of Michigan.

What drugs are being tested in NCT03875326?

Interventions in NCT03875326: 1 mA HD-tDCS, 2 mA HD-tDCS, 3 mA HD-tDCS, Sham.

What condition does NCT03875326 study?

NCT03875326 studies Mild Cognitive Impairment, Dementia of Alzheimer Type.

Is NCT03875326 still recruiting?

NCT03875326 is currently completed. Last updated 20 October 2025.

Last reviewed 2025-10-20 · How we verify

NCT03875326: STIM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Stimulation to Improve Memory

Completed NA Last updated 20 October 2025

What this trial tests

NA trial testing 1 mA HD-tDCS in Mild Cognitive Impairment in 269 participants. Completed in 19 December 2024.

Timeline

1 April 2019

Primary endpoint
6 December 2024

19 December 2024

Quick facts

Lead sponsor	University of Michigan
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	269
Start date	1 April 2019
Primary completion	6 December 2024
Estimated completion	19 December 2024
Sites	1 location across United States

Drugs / interventions tested

1 mA HD-tDCS
2 mA HD-tDCS
3 mA HD-tDCS
Sham

Conditions studied

Mild Cognitive Impairment — all drugs for Mild Cognitive Impairment →
Dementia of Alzheimer Type — all drugs for Dementia of Alzheimer Type →

Sponsor

University of Michigan

Who can join

50 and older, any sex, with Mild Cognitive Impairment or Dementia of Alzheimer Type. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will test the effects of different doses of a form of non-invasive brain stimulation for the treatment of individuals with mild cognitive impairment (MCI) and dementia of the Alzheimer's Type (DAT).

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Tolerability and blinding of high-definition transcranial direct current stimulation among older adults at intensities of up to 4 mA per electrode.
El Jamal C, Harrie A, Rahman-Filipiak A, Iordan AD, et al · · 2023 · cited 19× · PMID 37660936 · DOI 10.1016/j.brs.2023.08.025
High-definition transcranial direct current stimulation enhances network segregation during spatial navigation in mild cognitive impairment.
Iordan AD, Ryan S, Tyszkowski T, Peltier SJ, et al · · 2022 · cited 19× · PMID 35134853 · DOI 10.1093/cercor/bhac010
Salience network segregation mediates the effect of tau pathology on mild behavioral impairment.
Iordan AD, Ploutz-Snyder R, Ghosh B, Rahman-Filipiak A, et al · · 2024 · cited 5× · PMID 39364768 · DOI 10.1002/alz.14229
HD-tDCS as a neurorehabilitation technique for a case of post-anoxic leukoencephalopathy.
Garcia S, Hampstead BM. · · 2022 · cited 5× · PMID 33208043 · DOI 10.1080/09602011.2020.1845749

Verify or expand the search:

Other recruiting trials for Mild Cognitive Impairment

Currently open trials in the same condition.

NCT05791994 — EVASION: Effect of VisuAl Stimulation on attentION · NA · recruiting
NCT07169630 — PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI) · Phase 1 · recruiting
NCT07220694 — Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairmen · NA · recruiting
NCT06983769 — CPAP vs MAD for OSA in Patients With Cognitive Impairment. A Randomized Clinical Trial · NA · recruiting
NCT07318038 — The Use of Rhythmic Light Therapy in Mild Cognitive Impairment · NA · recruiting

Other University of Michigan trials

Trials by the same sponsor.

NCT07536919 — Integrating Care for Hypertension-Diabetes MULTImorbidity in Guatemala Through HEARTS Implementation · NA · not yet recruiting
NCT05509842 — Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD) · NA · not yet recruiting
NCT06311188 — Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness · NA · not yet recruiting
NCT07471646 — Effects of Ramadan Fasting With Exercise on Cardiometabolic Health · NA · not yet recruiting
NCT06671925 — A Community Health Worker-Led Program for Chronic Pain and Loneliness in Older Adults · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03875326 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Michigan
Last refreshed: 20 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03875326.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing