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NCT03873948
Evaluation of Arginine in Periodontal and Cardiovascular Disease
trial testing Evaluation of arginine serum level in Metabolic Disorder in 141 participants. Completed in 1 March 2019.
8 August 2018
Quick facts
| Lead sponsor | University of Messina |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 141 |
| Start date | 6 January 2014 |
| Primary completion | 8 August 2018 |
| Estimated completion | 1 March 2019 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Evaluation of arginine serum level
Conditions studied
- Metabolic Disorder — all drugs for Metabolic Disorder →
- Arginine; Hyperaminoaciduria — all drugs for Arginine; Hyperaminoaciduria →
Sponsor
University of Messina
Who can join
Adults 19 to 75, any sex, with Metabolic Disorder or Arginine; Hyperaminoaciduria. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Asymmetric dimethylarginine (ADMA) plays a key role in endothelial function and may be a link for the known interaction of periodontitis and coronary heart disease (CHD). The investigators compared the impact of gingival health, periodontitis (CP), CHD or of both diseases (CP+CHD) on saliva and serum ADMA levels.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Advancements and Challenges in Salivary Metabolomics for Early Detection and Monitoring of Systemic Diseases.
Zhao X, Chen X, Zhou Z, Zheng J, et al · · 2025 · cited 1× · PMID 40989572 · DOI 10.1002/mco2.70395
Verify or expand the search:
- PubMed search for NCT03873948
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University of Messina trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03873948 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Messina
- Last refreshed: 4 October 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03873948.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing