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NCT03872570
Effect of Phenylephrine Versus Norepinephrine on Venous Return
Phase 4 trial testing Phenylephrine in Arterial Hypotension in 40 participants. Status unknown.
1 June 2020
Quick facts
| Lead sponsor | Algemeen Ziekenhuis Maria Middelares |
|---|---|
| Phase | Phase 4 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | supportive care |
| Enrollment | 40 |
| Start date | 1 June 2019 |
| Primary completion | 1 June 2020 |
| Estimated completion | 15 June 2020 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Phenylephrine (phenylephrine) — full drug profile →
- Norepinephrine (NOREPINEPHRINE) — full drug profile →
Conditions studied
- Arterial Hypotension — all drugs for Arterial Hypotension →
Sponsor
Algemeen Ziekenhuis Maria Middelares — full company profile →
Who can join
Adults 18 to 85, female only, with Arterial Hypotension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Induction of general anesthesia often induces a decrease in the mean arterial blood pressure (MAP) caused by arterial and venous dilatation. Fluid administration is conventionally used to increase the patient's total blood volume, but is often associated with multiple adverse events such as postoperative edema. Arterial hypotension can also be treated by vasopressor agents such as norepinephrine and phenylephrine which mainly increase the blood pressure by arterial vasoconstriction. Compared to phenylephrine, norepinephrine has a shorter half-life (2 - 3 minutes) and improves the MAP by increase in cardiac contractility. In a recent study at our department it was demonstrated that besides arterial vasoconstriction, phenylephrine also improves venous return and cardiac output by venous vasoconstriction. The aim of this study is to compare the hemodynamic effects of both vasopressor agents in patients undergoing deep inferior epigastric perforators (DIEP) flap surgery. If significant differences between both agents are demonstrated, these findings can provide an important basis for future recommendations.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03872570
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Related trials
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Trials testing the same drug.
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- NCT06158009 — ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment · NA · unknown
- NCT06508359 — Norepinephrine and Phenylephrine for Spinal Anesthesia-induced Hypotension. · NA · not yet recruiting
Other recruiting trials for Arterial Hypotension
Currently open trials in the same condition.
- NCT06639737 — Preoperative Blood Volume Optimization Using Transthoracic Echocardiography · NA · recruiting
Other Algemeen Ziekenhuis Maria Middelares trials
Trials by the same sponsor.
- NCT05575141 — Robotic Versus Open Comparison in the Surgical Treatment of Wide Abdominal Wall heRnias (ROCSTAR) · NA · not yet recruiting
- NCT06080178 — Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction · Phase 4 · recruiting
- NCT06599515 — SetUp Study for HugoTM RAS Inguinal Hernia Repair · NA · recruiting
- NCT06835426 — High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins · NA · recruiting
- NCT05939206 — rTARUP: Long-term Analysis · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03872570 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Algemeen Ziekenhuis Maria Middelares
- Last refreshed: 11 October 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03872570.
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