Last reviewed · How we verify
NCT03871023: PROPEL
Prophylactic Negative Wound Therapy in Laparotomy Wounds.
NA trial testing Smith & Nephew PICO Negative wound pressure versus standard dresing in Wound Infection; Wounds; Dehisence; Cosmesis; Home Care; Length of Hospital Stay in 240 participants. Status unknown.
1 May 2020
Quick facts
| Lead sponsor | St. James's Hospital, Ireland |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 240 |
| Start date | 6 November 2019 |
| Primary completion | 1 May 2020 |
| Estimated completion | 1 December 2020 |
| Sites | 1 location across Ireland |
Drugs / interventions tested
- Smith & Nephew PICO Negative wound pressure versus standard dresing
- PREVENA Negative pressure wound versus standard dressing
Conditions studied
- Wound Infection; Wounds; Dehisence; Cosmesis; Home Care; Length of Hospital Stay — all drugs for Wound Infection; Wounds; Dehisence; Cosmesis; Home Care; Length of Hospital Stay →
Sponsor
St. James's Hospital, Ireland
Who can join
18 and older, any sex, with Wound Infection; Wounds; Dehisence; Cosmesis; Home Care; Length of Hospital Stay. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Post-operative wound issues in abdominal surgery have a significant impact on patient outcomes. The impact of different types of wound therapy are not clear in the literature. The hypothesis of this study is that NPWT has the potential to reduce Surgical Site Infections, however no study has compared the most commonly used products against standard dressings.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Shi C, Goh EL, Murphy EM, et al · · 2022 · cited 71× · PMID 35471497 · DOI 10.1002/14651858.cd009261.pub7 -
Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Goh EL, Dumville JC, Shi C, et al · · 2020 · cited 48× · PMID 32542647 · DOI 10.1002/14651858.cd009261.pub6 -
Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Goh EL, Dumville JC, Shi C, et al · · 2020 · cited 38× · PMID 32356396 · DOI 10.1002/14651858.cd009261.pub5 -
Prophylactic negative wound therapy in laparotomy wounds (PROPEL trial): randomized controlled trial.
Donlon NE, Boland PA, Kelly ME, Schmidt K, et al · · 2019 · cited 10× · PMID 31529194 · DOI 10.1007/s00384-019-03398-9
Verify or expand the search:
- PubMed search for NCT03871023
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other St. James's Hospital, Ireland trials
Trials by the same sponsor.
- NCT06550063 — HER2 Status in Esophagogastric Adenocarcinoma and Its Associations With Patient's Clinicopathological Outcomes · recruiting
- NCT05169645 — STOP CSUA: phySical acTivity, mOod and sleeP in Chronic Spontaneous Urticaria and Angioedema · unknown
- NCT04974931 — Application of PREVENA in Reducing Surgical Site Complications Following Reversal of Ileostomy or Colostomy · NA · unknown
- NCT04152044 — Obesity and Liver Function in Oesophageal Cancer · unknown
- NCT04151524 — Classification of Adenocarcinoma of the Esophagogastric Junction · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03871023 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by St. James's Hospital, Ireland
- Last refreshed: 18 September 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03871023.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing