Who is sponsoring NCT03868228?

NCT03868228 is sponsored by Imperial College London.

What drugs are being tested in NCT03868228?

Interventions in NCT03868228: Pressurised Intraperitoneal Aerosol Chemotherapy (PIPAC).

What condition does NCT03868228 study?

NCT03868228 studies Colorectal Neoplasms, Peritoneal Metastases.

Is NCT03868228 still recruiting?

NCT03868228 is currently status unknown. Last updated 28 September 2022.

Last reviewed 2022-09-28 · How we verify

NCT03868228

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

PIPAC for the Treatment of Colorectal Peritoneal Metastases

Status unknown Phase 1, PHASE2 Last updated 28 September 2022

What this trial tests

Phase 1, PHASE2 trial testing Pressurised Intraperitoneal Aerosol Chemotherapy (PIPAC) in Colorectal Neoplasms in 30 participants. Status unknown.

Timeline

5 February 2019

Primary endpoint
30 September 2024

30 September 2024

Quick facts

Lead sponsor	Imperial College London
Phase	Phase 1, PHASE2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	30
Start date	5 February 2019
Primary completion	30 September 2024
Estimated completion	30 September 2024
Sites	1 location across United Kingdom

Drugs / interventions tested

Pressurised Intraperitoneal Aerosol Chemotherapy (PIPAC)

Conditions studied

Colorectal Neoplasms — all drugs for Colorectal Neoplasms →
Peritoneal Metastases — all drugs for Peritoneal Metastases →

Sponsor

Imperial College London

Who can join

18 and older, any sex, with Colorectal Neoplasms or Peritoneal Metastases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study would like to assess the efficacy of pressurised intraperitoneal aerosol chemotherapy (PIPAC). This technique delivers chemotherapy directly into the abdomen via a less invasive laparoscopic or 'keyhole' form of surgery. This type of chemotherapy takes the form of an aerosol, similar to the spray of a deodorant for example. The aerosol is administered into the abdomen under pressure, pushing the chemotherapy deeper into the tissues and cancer. This approach does not involve any surgical removal of the cancer.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Pressurized intraperitoneal aerosol chemotherapy with oxaliplatin (PIPAC-OX) in patients with colorectal peritoneal metastases-a systematic review.
Lurvink RJ, Rovers KP, Nienhuijs SW, Creemers GJ, et al · · 2021 · cited 26× · PMID 33968441 · DOI 10.21037/jgo-20-257
The emergence of pressurized intraperitoneal aerosol chemotherapy as a palliative treatment option for patients with diffuse peritoneal metastases: a narrative review.
Lurvink RJ, Van der Speeten K, Rovers KP, de Hingh IHJT. · · 2021 · cited 18× · PMID 33968442 · DOI 10.21037/jgo-20-497
PIPAC for Gastrointestinal Malignancies.
Daniel SK, Sun BJ, Lee B. · · 2023 · cited 15× · PMID 37959264 · DOI 10.3390/jcm12216799
Patient-reported outcomes during repetitive oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy for isolated unresectable colorectal peritoneal metastases in a multicenter, single-arm, phase 2 trial (CRC-PIPAC).
Lurvink RJ, Rovers KP, Wassenaar ECE, Bakkers C, et al · · 2022 · cited 12× · PMID 34757489 · DOI 10.1007/s00464-021-08802-6
First-line palliative systemic therapy alternated with electrostatic pressurised intraperitoneal aerosol chemotherapy (oxaliplatin) for isolated unresectable colorectal peritoneal metastases: protocol of a multicentre, single-arm, phase II study (CRC-PIPAC-II).
Lurvink RJ, Rauwerdink P, Rovers KP, Wassenaar ECE, et al · · 2021 · cited 11× · PMID 33785492 · DOI 10.1136/bmjopen-2020-044811
UK trial of pressurised intraperitoneal aerosolised chemotherapy (PIPAC) with oxaliplatin for colorectal cancer peritoneal metastases (NCT03868228).
Kyle P, Perry K, Moutadjer A, Gilfillan N, et al · · 2023 · cited 4× · PMID 38144217 · DOI 10.1515/pp-2023-0008
Is PIPAC a Treatment Option in Upper and Lower Gastrointestinal Cancer with Peritoneal Metastasis?
Guel-Klein S, Alberto Vilchez ME, Ceelen W, Rau B, et al · · 2022 · cited 3× · PMID 35614892 · DOI 10.1159/000523901
Physiological Considerations and Delivery Strategies for Targeting Tumors Through Intraperitoneal Delivery.
Jony MJH, Ranjbar S, Prajapati R, Eslami SM, et al · · 2025 · cited 2× · PMID 40855029 · DOI 10.1007/s11095-025-03917-0

Verify or expand the search:

Other recruiting trials for Colorectal Neoplasms

Currently open trials in the same condition.

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Other Imperial College London trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03868228 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Imperial College London
Last refreshed: 28 September 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03868228.

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