NCT03867773

Time Restricted Feeding (4-hour Versus 6-hour) for Weight Loss in Obese Adults

Completed NA Last updated 24 June 2022

What this trial tests

NA trial testing Time restricted feeding in Obesity in 82 participants. Completed in 30 October 2019.

Timeline

1 February 2019

Primary endpoint
30 October 2019

30 October 2019

Quick facts

Lead sponsor	University of Illinois at Chicago
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	82
Start date	1 February 2019
Primary completion	30 October 2019
Estimated completion	30 October 2019
Sites	1 location across United States

Drugs / interventions tested

• Time restricted feeding

Conditions studied

• Obesity — all drugs for Obesity →
• Diabetes — all drugs for Diabetes →

Sponsor

University of Illinois at Chicago

Who can join

Adults 18 to 65, any sex, with Obesity or Diabetes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aims of this proposal are to compare the effects of 4-h versus 6-h time restricted feeding (TRF) on body weight and metabolic disease risk factors in adults with obesity. To test the study objectives, a 10-week randomized, controlled, parallel-arm trial, divided into 2 consecutive periods: (1) 2-week baseline period; and (2) 8-week TRF weight loss period, will be implemented. Obese subjects will be randomized to 1 of 3 groups: (1) 4-h TRF, (2) 6-h TRF, or a no-intervention control group. This study will be the first randomized controlled trial to compare 4-h versus 6-h TRF.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.
   Cienfuegos S, Gabel K, Kalam F, Ezpeleta M, et al · · 2020 · cited 424× · PMID 32673591 · DOI 10.1016/j.cmet.2020.06.018
2. Dietary regulation in health and disease.
   Wu Q, Gao ZJ, Yu X, Wang P. · · 2022 · cited 98× · PMID 35871218 · DOI 10.1038/s41392-022-01104-w
3. The effect of 4-h versus 6-h time restricted feeding on sleep quality, duration, insomnia severity and obstructive sleep apnea in adults with obesity.
   Cienfuegos S, Gabel K, Kalam F, Ezpeleta M, et al · · 2022 · cited 45× · PMID 33759620 · DOI 10.1177/02601060211002347
4. Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials.
   Gu L, Fu R, Hong J, Ni H, et al · · 2022 · cited 38× · PMID 35586738 · DOI 10.3389/fnut.2022.871682
5. Effect of time-restricted eating on sex hormone levels in premenopausal and postmenopausal females.
   Kalam F, Akasheh RT, Cienfuegos S, Ankireddy A, et al · · 2023 · cited 14× · PMID 36203273 · DOI 10.1002/oby.23562
6. Intermittent Fasting: Myths, Fakes and Truth on This Dietary Regimen Approach.
   Brogi S, Tabanelli R, Puca S, Calderone V. · · 2024 · cited 11× · PMID 38998465 · DOI 10.3390/foods13131960
7. Changes in body weight and metabolic risk during time restricted feeding in premenopausal versus postmenopausal women.
   Cienfuegos S, Gabel K, Kalam F, Ezpeleta M, et al · · 2021 · cited 10× · PMID 34478825 · DOI 10.1016/j.exger.2021.111545
8. Comparing caloric restriction regimens for effective weight management in adults: a systematic review and network meta-analysis.
   Huang J, Li Y, Chen M, Cai Z, et al · · 2024 · cited 6× · PMID 39327619 · DOI 10.1186/s12966-024-01657-9