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NCT03865589
Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome
NA trial testing Ultrasound Elastography in Bone Marrow Transplant Complications in 250 participants. Participants enrolled and being followed up; not accepting new ones.
30 June 2026
Quick facts
| Lead sponsor | Children's Mercy Hospital Kansas City |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 250 |
| Start date | 1 April 2019 |
| Primary completion | 30 June 2026 |
| Estimated completion | 30 June 2027 |
| Sites | 7 locations across United States |
Drugs / interventions tested
- Ultrasound Elastography
Conditions studied
- Bone Marrow Transplant Complications — all drugs for Bone Marrow Transplant Complications →
- Sinusoidal Obstruction Syndrome — all drugs for Sinusoidal Obstruction Syndrome →
- Veno Occlusive Disease, Hepatic — all drugs for Veno Occlusive Disease, Hepatic →
- Stem Cell Transplant Complications — all drugs for Stem Cell Transplant Complications →
Sponsor
Children's Mercy Hospital Kansas City
Who can join
Adults 1 Month to 99, any sex, with Bone Marrow Transplant Complications or Sinusoidal Obstruction Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To perform an receiver operating characteristic (ROC) analysis, define a threshold and quantify the sensitivity and specificity of US SWE for risk stratification of patients into three categories as defined by the European Bone Marrow Transplant (EBMT) adult and pediatric criteria: no sinusoidal obstruction syndrome (SOS), mild to moderate SOS, and severe to very severe SOS. Secondarily, the investigators would also like to quantify the temporal relationship between US SWE changes and SOS diagnosis according to various clinical criteria (Modified Seattle, Baltimore, EBMT consortium).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03865589
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Ultrasound Elastography
Trials testing the same drug.
- NCT07486284 — Ultrasound Elastography of Carpal Tunnel Syndrome · enrolling by invitation
- NCT07428720 — Axillary Lymph Node Changes After Neoadjuvant Therapy In Breast Cancer · NA · active not recruiting
- NCT05363735 — Ultrasound Elastography Application in Cesarean Section Scar Defect · withdrawn
- NCT03963999 — Validating Ultrasound Biomarkers for Hepatic Sinusoidal Obstruction Syndrome in Pediatric Hematopoietic Cell Transplant · Phase 4 · withdrawn
- NCT04130048 — Thrombus Elastography in Venous Thrombo-Embolism. · unknown
Other recruiting trials for Bone Marrow Transplant Complications
Currently open trials in the same condition.
- NCT06590285 — Diagnostic Refinement and Educational Approaches in Managing Bone Marrow Transplantation · NA · recruiting
- NCT06910969 — Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease · NA · recruiting
- NCT06541002 — A Novel Digital Application (SHIFT) to Improve Outcomes for Hematopoietic Stem Cell Transplant Survivors · NA · recruiting
- NCT05709912 — Mobile CARE-App to Promote Coping for Caregivers of Patients Receiving Stem Cell Transplant · NA · active not recruiting
- NCT05629676 — Virtual Reality Intervention for Patients Undergoing BMT · NA · active not recruiting
Other Children's Mercy Hospital Kansas City trials
Trials by the same sponsor.
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- NCT07195032 — Safety and Efficacy of Measles, Mumps, Rubella Vaccination in Pediatric Heart Transplantation Patients · Phase 4 · recruiting
- NCT06834594 — Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome · Phase 4 · recruiting
- NCT06738121 — Cosmetic Outcomes of Umbilical Hernia Incisions · NA · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03865589 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Mercy Hospital Kansas City
- Last refreshed: 8 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03865589.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing