NCT03865498 (Tweet-S2) is a NA clinical trial of Twitter for Hispanic caregivers in Loneliness, sponsored by Columbia University.

Who is sponsoring NCT03865498?

NCT03865498 is sponsored by Columbia University.

What drugs are being tested in NCT03865498?

Interventions in NCT03865498: Twitter for Hispanic caregivers, Twitter for African American caregivers.

What condition does NCT03865498 study?

NCT03865498 studies Loneliness, Emotional Stress.

Is NCT03865498 still recruiting?

NCT03865498 is currently completed. Last updated 15 January 2025.

Are results published for NCT03865498?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2025-01-15 · How we verify

NCT03865498: Tweet-S2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Twitter Based Social Support for Hispanic and Black Dementia Caregivers

Completed NA Results posted Last updated 15 January 2025

What this trial tests

NA trial testing Twitter for Hispanic caregivers in Loneliness in 966 participants. Completed in 20 November 2023.

Timeline

12 January 2022

Primary endpoint
31 October 2023

20 November 2023

Quick facts

Lead sponsor	Columbia University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	966
Start date	12 January 2022
Primary completion	31 October 2023
Estimated completion	20 November 2023
Sites	1 location across United States

Drugs / interventions tested

Twitter for Hispanic caregivers
Twitter for African American caregivers

Conditions studied

Loneliness — all drugs for Loneliness →
Emotional Stress — all drugs for Emotional Stress →

Sponsor

Columbia University

Who can join

18 and older, any sex, with Loneliness or Emotional Stress. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of Participants Who do Not Engage in Twitter Activities Primary · 12 months

Macro level: The number of participants who do not engage in Twitter activities (i.e., retweet, reply, like, post) within the Twitter network for dementia caregivers

Group	Value	95% CI
African American Family Members of Persons With Alzheimer's Disease and Related Dementias	246
Hispanic Family Members of Persons With Alzheimer's Disease and Related Dementias	226

Emotional Valence Score Primary · 12 months

Emotional valence (macro level) detected from text data (e.g., "This is so helpful": emotion score +4; "I am sad": emotion score -6). Emotional valence score ranges from -10 to +10; -10 indicates negative valence and +10 indicates positive valence.

Group	Value	95% CI
African American Family Members of Persons With Alzheimer's Disease and Related Dementias	1.404	± 2.412
Hispanic Family Members of Persons With Alzheimer's Disease and Related Dementias	1.483	± 2.229

Number of Auto-detected Small Groups Secondary · 12 months

Meso level: number of small group automatically detected based on Twitter activities (i.e., retweet); for example 0 means no small-group activity detected, 7 small groups mean seven distinct cliques/grouping activities detected where the users are communicating, supporting and responding within our Twitter network.

Pre

Group	Value	95% CI
African American Family Members of Persons With Alzheimer's Disease and Related Dementias	259
Hispanic Family Members of Persons With Alzheimer's Disease and Related Dementias	231

Post

Group	Value	95% CI
African American Family Members of Persons With Alzheimer's Disease and Related Dementias	262
Hispanic Family Members of Persons With Alzheimer's Disease and Related Dementias	239

Percentage of Balanced Triads Secondary · 12 months

Micro level: % balanced communication triad, 2 or 3 people responding and communicating with equal or similar frequency; 0 reflects non-optimal communication indicating domination, avoidance or ignorance. 8 means there are 8% triads who maintain healthy communication.

Pre

Group	Value	95% CI
African American Family Members of Persons With Alzheimer's Disease and Related Dementias	0.00
Hispanic Family Members of Persons With Alzheimer's Disease and Related Dementias	0.00

Post

Group	Value	95% CI
African American Family Members of Persons With Alzheimer's Disease and Related Dementias	0.21
Hispanic Family Members of Persons With Alzheimer's Disease and Related Dementias	0.34

Sponsor's own description

The prevalence of dementia is higher in Hispanics and African Americans than non-Hispanic Whites. Moreover, dementia caregivers often experience loneliness as well decreased health status. The expansion of social media use among Hispanics and African Americans, particularly Twitter - a short message service - offers great promise for improving social support. This study aims to evaluate changes of discussion topics, sentiment and networking styles (i.e., number of followers) among anonymous followers of our two Twitter networks; the African American/Black dementia caregiver group and the Hispanic dementia caregiver group.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Using Natural Language Processing on Expert Panel Discussions to Gain Insights for Recruitment, Retention and Intervention Adherence for Online Social Support Interventions on a Stage II-III Clinical Trial Among Hispanic and African American Dementia Caregivers.
Odlum M, Moon S, Broadwell P, Huang N, et al · · 2024 · cited 1× · PMID 39176734 · DOI 10.3233/shti240405
Comparing Emotional Valence Scores of Twitter Messages from Human Coding and Machine Learning Algorithms Among Hispanic and African American Family Caregivers of Persons with Dementia.
Yoon S, Broadwell P, Tipiani D, Bristol A, et al · · 2023 · cited 1× · PMID 37387060 · DOI 10.3233/shti230526

Verify or expand the search:

Other recruiting trials for Loneliness

Currently open trials in the same condition.

NCT07486050 — The Impact of Social Worker Referrals on Diabetes and Loneliness · NA · active not recruiting
NCT07443813 — An Innovative App-based Intervention to Promote Social Connectedness and Well-being in Older Adults · NA · active not recruiting
NCT07305701 — Cohort Study on Medical Students' Mental Health · recruiting
NCT07107906 — Evaluating and Implementing The CONNECT Program - a Group-Based Telehealth Intervention to Reduce Social Isolation, Lone · NA · recruiting
NCT06919094 — A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults · NA · recruiting

Other Columbia University trials

Trials by the same sponsor.

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NCT05992415 — Know Your Pressures NYC · NA · not yet recruiting
NCT05645211 — The AgRP and GH/IGF-1 Axis in Children · not yet recruiting
NCT07403604 — Effect of Insulin Lowering on Lipogenesis · Phase 1 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03865498 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Columbia University
Last refreshed: 15 January 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03865498.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing