Who is sponsoring NCT03863054?

NCT03863054 is sponsored by Singapore General Hospital.

What drugs are being tested in NCT03863054?

Interventions in NCT03863054: NATROX™ Topical Oxygen Therapy System.

What condition does NCT03863054 study?

NCT03863054 studies Diabetic Foot Ulcer, Non-healing Wound.

Is NCT03863054 still recruiting?

NCT03863054 is currently completed. Last updated 27 September 2021.

Last reviewed 2021-09-27 · How we verify

NCT03863054

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (NATROX™) on the Rates of Healing of Chronic Diabetic Foot Ulcers

Completed Last updated 27 September 2021

What this trial tests

trial testing NATROX™ Topical Oxygen Therapy System in Diabetic Foot Ulcer in 20 participants. Completed in 31 May 2021.

Timeline

17 August 2018

Primary endpoint
23 March 2021

31 May 2021

Quick facts

Lead sponsor	Singapore General Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	20
Start date	17 August 2018
Primary completion	23 March 2021
Estimated completion	31 May 2021
Sites	1 location across Singapore

Drugs / interventions tested

NATROX™ Topical Oxygen Therapy System

Conditions studied

Diabetic Foot Ulcer — all drugs for Diabetic Foot Ulcer →
Non-healing Wound — all drugs for Non-healing Wound →

Sponsor

Singapore General Hospital

Who can join

Adults 21 to 90, any sex, with Diabetic Foot Ulcer or Non-healing Wound. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to evaluate the effectiveness of NATROX™ Topical Oxygen Wound Therapy for subjects with non-healing foot ulceration. Subjects will be treated with standard care for 4 weeks. If the wound is not reduced by more than 40%, NATROX™ will be applied for the next 12 weeks. Throughout the study period, wound measurements will be taken to measure wound reduction.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Updates on Recent Clinical Assessment of Commercial Chronic Wound Care Products.
Sharma A, Sharma D, Zhao F. · · 2023 · cited 29× · PMID 37306401 · DOI 10.1002/adhm.202300556
An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox<sup>™</sup>) on the Rates of Healing of Chronic DiAbetic Foot Ulcers (OTONAL Trial).
Tang TY, Mak MYQ, Yap CJQ, Boey JEC, et al · · 2024 · cited 13× · PMID 34747267 · DOI 10.1177/15347346211053694
Advances in nucleic acid delivery strategies for diabetic wound therapy.
Sarthi S, Bhardwaj H, Kumar Jangde R. · · 2024 · cited 4× · PMID 39286540 · DOI 10.1016/j.jcte.2024.100366

Verify or expand the search:

Other recruiting trials for Diabetic Foot Ulcer

Currently open trials in the same condition.

NCT07161830 — Evaluating the Efficacy of OCM™ (Omeza® Complete Matrix) in the Treatment of Diabetic Foot Ulcers · NA · recruiting
NCT07396376 — Evaluation of ELU42 Topical Spray for the Treatment of Diabetic Foot Ulcers · Phase 1, PHASE2 · recruiting
NCT07291817 — Intermittent Negative Pressure for Patients With Diabetic Foot Ulcers (INPRESS) Study · NA · recruiting
NCT07209358 — EDX110 Randomized Control Trial for Treatment of DFUs · NA · recruiting
NCT06938685 — Evaluating the Efficacy NeoThelium FT in the Treatment of Diabetic Foot Ulcers · NA · recruiting

Other Singapore General Hospital trials

Trials by the same sponsor.

NCT07452159 — Diabetes In Asians at Risk in Youth · not yet recruiting
NCT07527247 — Improving Vaccine Protection for Older Adults · Phase 2 · recruiting
NCT07533188 — Patient Outcomes Following Kinematic and Functional Alignment in Robotic-Assisted Total Knee Arthroplasty With Randomize · NA · recruiting
NCT07042061 — Trial of Mobile External Defibrillator for Out-of-hospital Cardiac Arrest in Singapore. · NA · not yet recruiting
NCT07099040 — Community-based Multi-domain Intervention to Detect and Delay Cognitive Decline in Community-dwelling Older Adults: A Pi · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03863054 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Singapore General Hospital
Last refreshed: 27 September 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03863054.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing