Adults 18 to 35, female only, with Premenstrual Dysphoric Disorder. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Hormone AnalysisPrimary· -20, +20, +30, +40, +50, +65, +90 minutes in the late luteal phase of the menstrual cycle (one day between -1 to -6 days of the subsequent menstrual cycle)
Cortisol
-20 minute timepoint
Group
Value
95% CI
PMDD Patients
70.7
± 26.4
Healthy Controls
57.8
± 21.9
+20 minute timepoint
Group
Value
95% CI
PMDD Patients
114
± 53.4
Healthy Controls
97.3
± 39.9
+30 minute timepoint
Group
Value
95% CI
PMDD Patients
111
± 43.6
Healthy Controls
109
± 43.6
+40 minute timepoint
Group
Value
95% CI
PMDD Patients
97
± 48.9
Healthy Controls
100
± 32.4
+50 minute timepoint
Group
Value
95% CI
PMDD Patients
86.9
± 39.4
Healthy Controls
93.3
± 29.2
+65 minute timepoint
Group
Value
95% CI
PMDD Patients
73.5
± 31.6
Healthy Controls
78.4
± 24
+90 minute timepoint
Group
Value
95% CI
PMDD Patients
70.6
± 36.6
Healthy Controls
69
± 18.5
Sponsor's own description
PHASE is designed to evaluate neuroactive hormone trajectories across the menstrual cycle and endocrine, autonomic, and subjective responses to psychosocial stress in women suffering from severe PMS (i.e., premenstrual dysphoric disorder).
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Illinois at Chicago
Last refreshed: 24 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03862469.