NCT03860766

Photobiomodulation in Different Doses on Strength Capacities and Functional Performance

Completed NA Last updated 21 July 2021

What this trial tests

NA trial testing Photobiomodulation in Low Level Laser Therapy in 56 participants. Completed in 19 July 2021.

Timeline

8 July 2020

Primary endpoint
19 July 2021

19 July 2021

Quick facts

Lead sponsor	University of Sao Paulo
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	other
Enrollment	56
Start date	8 July 2020
Primary completion	19 July 2021
Estimated completion	19 July 2021
Sites	1 location across Brazil

Drugs / interventions tested

• Photobiomodulation

Conditions studied

• Low Level Laser Therapy — all drugs for Low Level Laser Therapy →
• Performance — all drugs for Performance →
• Sport — all drugs for Sport →

Sponsor

University of Sao Paulo

Who can join

Adults 18 to 40, male only, with Low Level Laser Therapy or Performance. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background: Photobiomodulation has been explored for years, with wide clinical use for wound healing and analgesia in varied orthopedic conditions, but the number of research and clinical use has increased during the last decade. Furthermore, considering the performance, the current literature is conflicting and restricted, with divergences in wavelength, power and energy density applied. Therefore, analyze different doses for a answer in short and long time, associated with capacities of strength, fatigue resistance and functional performance of handball players and healthy individuals becomes necessary. Objective: To analyze the effects of the application of LED photobiomodulation on the capacities of strength, functional efficiency, temperature and fatigue resistance of handball players and healthy individuals. Method: The study sample will be composed of 56 male individuals randomly allocated into four groups: LED 50J (G-50J), LED 240J (G-240J), LED 50-240J (G-50-240J) - progressive dose and Sham (G-S). The volunteers will be submitted to an evaluation of muscle performance and functional performance, metabolic, and physiological evaluation. After initial tests, in five consecutive weeks, the LEDT (940nm - infrared) will be applied to the quadriceps femoris muscle and hamstrings, bilaterally, associated with a muscle strength protocol. After 24 hours of the last application TLED, the tests will be repeated. Seven days after the last intervention will be performed a follow-up. For analysis, normality tests will be used to verify the distribution and adequate statistical tests for the appropriate intra and intergroup comparisons, being considered two factors in the comparisons, time, and group. A significance level of 5% will be adopted.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Impact of Photobiomodulation Therapy Dosing Strategies on Strength, Clinical Outcomes, and Metabolic Responses: A Blinded Randomized Clinical Trial.
   Girasol CE, Caseiro Filho LC, Ferraz Moraes JMA, Rinaldi ML, et al · · 2025 · PMID 40851926 · DOI 10.34172/jlms.2025.14