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NCT03860350: AGE
Aged Garlic Extract Study
NA trial testing Aged Garlic Extract in Coronary Artery Disease in 100 participants. Completed in 1 June 2019.
1 June 2019
Quick facts
| Lead sponsor | Lund University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | other |
| Enrollment | 100 |
| Start date | 1 December 2016 |
| Primary completion | 1 June 2019 |
| Estimated completion | 1 June 2019 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Aged Garlic Extract — full drug profile →
- Placebo
Conditions studied
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
- Microcirculation — all drugs for Microcirculation →
- Biomarkers — all drugs for Biomarkers →
Sponsor
Lund University Hospital
Who can join
Adults 40 to 75, any sex, with Coronary Artery Disease or Microcirculation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary intention of the study is to examine the effect of aged garlic extract (AGE) on the absolute change in coronary artery calcium (CAC). The second intention is to examine the effect of AGE on inflammatory biomarkers and microcirculation. It is a double blind placebo controlled study. The participants will ingest AGE during a period of one year. The CAC will be controlled by computer tomography (CT) scan; the inflammatory biomarkers through blood sample test and the microcirculation through laser speckel imagining and laser doppler before and after the one year period of AGE ingestion.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
The landscape of aging.
Cai Y, Song W, Li J, Jing Y, et al · · 2022 · cited 312× · PMID 36066811 · DOI 10.1007/s11427-022-2161-3 -
The effect of aged garlic extract on the atherosclerotic process - a randomized double-blind placebo-controlled trial.
Wlosinska M, Nilsson AC, Hlebowicz J, Hauggaard A, et al · · 2020 · cited 29× · PMID 32349742 · DOI 10.1186/s12906-020-02932-5 -
Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases: A double-blinded placebo-controlled study.
Wlosinska M, Nilsson AC, Hlebowicz J, Malmsjö M, et al · · 2019 · cited 22× · PMID 31518044 · DOI 10.1111/iwj.13220 -
Successful improved peripheral tissue perfusion was seen in patients with atherosclerosis after 12 months of treatment with aged garlic extract.
Lindstedt S, Wlosinska M, Nilsson AC, Hlebowicz J, et al · · 2021 · cited 15× · PMID 33590955 · DOI 10.1111/iwj.13570 -
Aged Garlic Extract Reduces IL-6: A Double-Blind Placebo-Controlled Trial in Females with a Low Risk of Cardiovascular Disease.
Wlosinska M, Nilsson AC, Hlebowicz J, Fakhro M, et al · · 2021 · cited 12× · PMID 33868439 · DOI 10.1155/2021/6636875 -
Aged Garlic Extract and Its Bioactive Molecules S-Allyl-Cysteine and S1-Propenyl-Cysteine: A Review Focusing on Evidences Supporting Their Use for Mitigating the Effects of Cigarette Smoking.
Gambari R, Finotti A. · · 2025 · cited 1× · PMID 40942024 · DOI 10.3390/molecules30173496
Verify or expand the search:
- PubMed search for NCT03860350
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Aged Garlic Extract
Trials testing the same drug.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03860350 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Lund University Hospital
- Last refreshed: 11 June 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03860350.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing