Adults 18 to 65, any sex, with CSF Circulation. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
CSF Flow VelocitiesPrimary· Baseline (pre-intervention) and post-intervention (after 8 weeks).
We have collected cerebrospinal fluid (CSF) flow measurements during a set of breathing practices while subjects were inside the MRI scanner. MRI-based CSF flow was quantified at the level of Foramen Magnum. Data processing included the extraction of velocity waveforms of the CSF motion ( i.e, CSF velocity in cm/s) and subsequent analysis of CSF velocities across different breathing conditions. Positive CSF velocities indicate fluid motion in the cranial (upward) direction, whereas negative velocities represent fluid motion in the caudal (downward) direction.
For the registry, descriptive sta
Pre-intervention maximum (cranially directed) CSF velocity during natural breathing
Group
Value
95% CI
Breathing Group 1
1.36
± 0.27
Breathing Group 2
1.31
± 0.23
Post-intervention maximum (cranially directed) CSF velocity during natural breathing
Group
Value
95% CI
Breathing Group 1
1.48
± 0.42
Breathing Group 2
1.15
± 0.25
Pre-intervention minimum (caudally directed) CSF velocity during natural breathing
Group
Value
95% CI
Breathing Group 1
-1.92
± 0.51
Breathing Group 2
-1.73
± 0.41
Post-intervention minimum (caudally directed) CSF velocity during natural breathing
Group
Value
95% CI
Breathing Group 1
-1.68
± 0.47
Breathing Group 2
-1.84
± 0.45
Pre-intervention maximum (cranially directed) CSF velocity during slow breathing
Group
Value
95% CI
Breathing Group 1
1.76
± 0.62
Breathing Group 2
1.48
± 0.37
Post-intervention maximum (cranially directed) CSF velocity during slow breathing
Group
Value
95% CI
Breathing Group 1
1.56
± 0.45
Breathing Group 2
1.35
± 0.43
Pre-intervention minimum (caudally directed) CSF velocity during slow breathing
Group
Value
95% CI
Breathing Group 1
-2.15
± 0.63
Breathing Group 2
-1.68
± 0.48
Post-intervention minimum (caudally directed) CSF velocity during slow breathing
Group
Value
95% CI
Breathing Group 1
-1.80
± 0.37
Breathing Group 2
-1.94
± 0.66
Systolic and Diastolic Blood PressureSecondary· Baseline (pre-intervention) and post-intervention (after 8 weeks).
Systolic and diastolic blood pressure were measured participants seated at rest at pre- and post-intervention visits.
Pre-intervention systolic blood pressure
Group
Value
95% CI
Breathing Group 1
128.11
± 16.07
Breathing Group 2
117.71
± 7.99
Post-intervention systolic blood pressure
Group
Value
95% CI
Breathing Group 1
125.62
± 4.55
Breathing Group 2
118.29
± 7.99
Pre-intervention diastolic blood pressure
Group
Value
95% CI
Breathing Group 1
80.22
± 4.08
Breathing Group 2
66.29
± 4.15
Post-intervention diastolic blood pressure
Group
Value
95% CI
Breathing Group 1
76.00
± 3.46
Breathing Group 2
63.43
± 4.15
Body Mass Index (BMI)Secondary· Baseline (pre-intervention) and post-intervention (after 8 weeks).
BMI was collected at pre- and post-intervention visits, and was calculated as weight in kilograms divided by height in meters squared (kg/m²).
Pre-Intervention BMI
Group
Value
95% CI
Breathing Group 1
25.33
± 1.66
Breathing Group 2
24.33
± 1.56
Post-Intervention BMI
Group
Value
95% CI
Breathing Group 1
25.16
± 1.57
Breathing Group 2
24.46
± 1.56
Daily Home Practice FrequencySecondary· 8 weeks (daily home practice over the course of 8-week intervention).
Average breathing practice frequency were measured using a wearable respiration tracker to objectively evaluate home practice throughout the intervention: frequency (days/week). Preliminary analysis estimated mean frequency (days/week) across participants. Onsite class sessions were excluded.
Group
Value
95% CI
Breathing Group 1
5.00
± 0.82
Breathing Group 2
5.43
± 0.80
Daily Home Practice DurationSecondary· 8 weeks (daily home practice over the course of 8-week intervention).
Average breathing practice duration were measured using a wearable respiration tracker to objectively evaluate home practice throughout the intervention: duration (in minute). Preliminary analysis estimated mean duration (minutes) across participants. Onsite class sessions were excluded.
Group
Value
95% CI
Breathing Group 1
21.80
± 2.27
Breathing Group 2
20.22
± 0.54
Sponsor's own description
The purpose of this research study is to determine the influence of yoga breathing practices on cerebrospinal fluid (CSF) circulation, and to find out primarily if a regular practice of 8-week yoga breathing would enhance CSF circulation as well as if the intervention would improve participant's quality of life, quality of sleep, and reduce existing stress. Participants will be randomized into two arms for different breathing practices.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Oregon Health and Science University
Last refreshed: 29 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03858309.