NCT03858218

Validation of the Chinese Version of the Pittsburgh Sleep Quality Index in Hong Kong Childhood Cancer Survivors

Completed Last updated 30 March 2020

What this trial tests

trial testing questionnaires set in Health-Related Quality Of Life in 300 participants. Completed in 16 January 2020.

Timeline

1 November 2018

Primary endpoint
16 January 2020

16 January 2020

Quick facts

Lead sponsor	The University of Hong Kong
Status	Completed
Study type	OBSERVATIONAL
Enrollment	300
Start date	1 November 2018
Primary completion	16 January 2020
Estimated completion	16 January 2020
Sites	1 location across Hong Kong

Drugs / interventions tested

• questionnaires set

Conditions studied

• Health-Related Quality Of Life — all drugs for Health-Related Quality Of Life →

Sponsor

The University of Hong Kong

Who can join

Adults 9 to 17, any sex, with Health-Related Quality Of Life. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Cancer is one of the major causes of death in pediatric population. In Hong Kong, childhood cancer remains a significant concern in healthcare system because of its damaging impacts on adolescent's physical and psychological functions throughout their lifespan. Particularly, adolescents surviving cancer still have to bear the health burden of numerous sequelae, even their treatment is completed for months and even years.

One of the most prevalent symptoms reported by patients surviving cancer is sleep disturbance. The causes of sleep disturbance are multifactorial. However, it can largely be attributed to disruption of circadian rhythm by prolonged use of medications and long-term hospitalization. Experiencing sleep disturbance can be devastating for survivors of cancer and precipitates inflammation and oxidative stress, which are known to be a contributing factor of neurocognitive impairment. Sleep disturbance can also lead to fatigue, which in turn limits patients' capacity in engaging in daily activities and even results in depression, severely compromising patients' quality of life in the long run. Having a reliable and valid instrument that can precisely assess the problem of sleep disturbance of cancer survivors is therefore crucial for the development and evaluation of the intervention.

The Pittsburgh Sleep Quality Index (PSQI) is the most commonly and frequently used instrument to assess sleep disturbance. Because of differences in culture and language, some concepts or items in the English version may be inappropriate for adolescents living in Hong Kong. Moreover, the psychometrics of the PSQI has only been established in adolescents undergoing active treatment for cancer, when they experienced the most severe problem. It is therefore unclear whether the PSQI can also be used to assess sleep disturbance of adolescents who have completed cancer treatment. This lack of validated instruments precludes us from understanding the severity of the problem. Also, it hinders the development of appropriate interventions that promote sleep quality. This study aims to bridge the gap in existing literature by translating the PSQI from English into Chinese, and examining the psychometrics of the translated PSQI in Hong Kong Chinese childhood cancer survivors.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Psychometric properties of the Chinese version of the Pittsburgh Sleep Quality Index (PSQI) among Hong Kong Chinese childhood cancer survivors.
   Ho KY, Lam KKW, Xia W, Chung JOK, et al · · 2021 · cited 69× · PMID 34229705 · DOI 10.1186/s12955-021-01803-y
2. Psychometric Properties of the Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) Among Hong Kong Chinese Childhood Cancer Survivors
   HO KY, Lam KK, W X, Chung J, et al · · 2021 · DOI 10.21203/rs.3.rs-435552/v1