NCT03857971: PECTUS-obs

Identification of Risk Factors for Acute Coronary Events by OCT After STEMI and NSTEMI in Patients With Residual Non-flow Limiting Lesions

Status unknown NA Last updated 17 September 2021

What this trial tests

NA trial testing Coronary Optical Coherence tomography in Myocardial Infarction in 438 participants. Status unknown.

Timeline

14 December 2018

Primary endpoint
15 September 2022

14 June 2025

Quick facts

Lead sponsor	Radboud University Medical Center
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	438
Start date	14 December 2018
Primary completion	15 September 2022
Estimated completion	14 June 2025
Sites	1 location across Netherlands

Drugs / interventions tested

• Coronary Optical Coherence tomography

Conditions studied

• Myocardial Infarction — all drugs for Myocardial Infarction →
• Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →
• Coronary Artery Disease — all drugs for Coronary Artery Disease →

Sponsor

Radboud University Medical Center

Who can join

18 and older, any sex, with Myocardial Infarction or Acute Coronary Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this study is to compare the clinical outcome of Non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) patients with non-obstructive, non-culprit coronary lesions and either presence or absence of vulnerable plaque characteristics as assessed by optical coherence tomography (OCT).

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Identification of anatomic risk factors for acute coronary events by optical coherence tomography in patients with myocardial infarction and residual nonflow limiting lesions: rationale and design of the PECTUS-obs study.
   Mol JQ, Belkacemi A, Volleberg RH, Meuwissen M, et al · · 2021 · cited 12× · PMID 34233996 · DOI 10.1136/bmjopen-2021-048994
2. Pre-Emptive OCT-Guided Angioplasty of Vulnerable Intermediate Coronary Lesions: Results from the Prematurely Halted PECTUS-Trial.
   Mol JQ, Bom MJ, Damman P, Knaapen P, et al · · 2020 · cited 11× · PMID 33363447 · DOI 10.1155/2020/8821525
3. FFR-Negative Nonculprit High-Risk Plaques and Clinical Outcomes in High-Risk Populations: An Individual Patient-Data Pooled Analysis From COMBINE (OCT-FFR) and PECTUS-obs.
   Volleberg RHJA, Rroku A, Mol JQ, Hermanides RS, et al · · 2025 · cited 10× · PMID 39840429 · DOI 10.1161/circinterventions.124.014667
4. High-risk plaques in non-culprit lesions and clinical outcome after NSTEMI vs. STEMI.
   Volleberg RHJA, Mol JQ, Belkacemi A, Hermanides RS, et al · · 2025 · cited 4× · PMID 39512201 · DOI 10.1093/ehjci/jeae289
5. Recent developments in diagnosis and risk stratification of non-ST-elevation acute coronary syndrome.
   Aarts GWA, Mol JQ, Camaro C, Lemkes J, et al · · 2020 · cited 4× · PMID 32780337 · DOI 10.1007/s12471-020-01457-3
6. Artificial intelligence-based identification of thin-cap fibroatheromas and clinical outcomes: the PECTUS-AI study.
   Volleberg RHJA, Luttikholt TJ, van der Waerden RGA, Cancian P, et al · · 2025 · cited 2× · PMID 40888677 · DOI 10.1093/eurheartj/ehaf595
7. Intracoronary Diagnostics in Patients with Acute Coronary Syndrome.
   Sun Q, Liu M, Zeng M, Jia H. · · 2023 · cited 1× · PMID 39077404 · DOI 10.31083/j.rcm2402045
8. Long-Term Clinical Outcomes of High-Risk Plaques with Negative fractional flow reserve: the PECTUS-obs study.
   Volleberg RHJA, Mol JQ, Versteeg GAA, van der Zande J, et al · · 2026 · PMID 42200638 · DOI 10.4244/eij-d-26-00416