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NCT03856918
Optimal Level of PEEP in Protective One-lung Ventilation
NA trial testing PEEP 3 cm of water in Video-assisted Thoracic Surgery in 142 participants. Completed in 28 February 2021.
11 February 2020
Quick facts
| Lead sponsor | Seoul National University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 142 |
| Start date | 28 May 2019 |
| Primary completion | 11 February 2020 |
| Estimated completion | 28 February 2021 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- PEEP 3 cm of water
- PEEP 6 cm of water
- PEEP 9 cm of water
Conditions studied
- Video-assisted Thoracic Surgery — all drugs for Video-assisted Thoracic Surgery →
- Postoperative Atelectasis — all drugs for Postoperative Atelectasis →
- Positive End-expiratory Pressure — all drugs for Positive End-expiratory Pressure →
Sponsor
Seoul National University Hospital
Who can join
Adults 19 to 80, any sex, with Video-assisted Thoracic Surgery or Postoperative Atelectasis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Protective ventilation strategy has been widely applied in the field of thoracic surgery requiring one-lung ventilation to reduce postoperative pulmonary complications. Low tidal volume, positive end-expiratory pressure (PEEP), and intermittent recruitment maneuver are key components of protective ventilation strategy. Recent evidence suggests that a tidal volume of 4-5 ml/kg should be applied during protective one-lung ventilation. However, optimal level of PEEP is still unclear. This study aims to investigate optimal level of PEEP to minimize postoperative atelectasis by comparing modified lung ultrasound score in patients applied protective one-lung ventilation using PEEP of 3, 6, or 9 cm of water during thoracic surgery.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A nationwide survey of intraoperative management for one-lung ventilation in Taiwan: time to accountable for diversity in protective lung ventilation.
Kuo CY, Liu YT, Chen TS, Lam CF, et al · · 2020 · cited 6× · PMID 32938385 · DOI 10.1186/s12871-020-01157-w
Verify or expand the search:
- PubMed search for NCT03856918
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03856918 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Seoul National University Hospital
- Last refreshed: 18 April 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03856918.
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