Who is sponsoring NCT03856424?

NCT03856424 is sponsored by Piquilloud Imboden Lise.

What drugs are being tested in NCT03856424?

Interventions in NCT03856424: Modality 1, Modality 2, Modality 3.

What condition does NCT03856424 study?

NCT03856424 studies Mechanical Ventilation Complication.

Is NCT03856424 still recruiting?

NCT03856424 is currently status unknown. Last updated 3 June 2022.

Last reviewed 2022-06-03 · How we verify

NCT03856424: TWEEP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Three Modalities of Spontaneous Breathing Tests on Respiratory Efforts in Tracheostomized Patients

Status unknown NA Last updated 3 June 2022

What this trial tests

NA trial testing Modality 1 in Mechanical Ventilation Complication in 18 participants. Status unknown.

Timeline

8 March 2019

Primary endpoint
30 June 2023

30 December 2023

Quick facts

Lead sponsor	Piquilloud Imboden Lise
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	other
Enrollment	18
Start date	8 March 2019
Primary completion	30 June 2023
Estimated completion	30 December 2023
Sites	1 location across Switzerland

Drugs / interventions tested

Modality 1
Modality 2
Modality 3

Conditions studied

Mechanical Ventilation Complication — all drugs for Mechanical Ventilation Complication →

Sponsor

Piquilloud Imboden Lise

Who can join

18 and older, any sex, with Mechanical Ventilation Complication. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Datas are lacking concerning weaning from mechanical ventilation for tracheostomized patients. In particular, the effect of different modalities of spontaneous breathing trials on respiratory effort has not been extensively described. This crossover physiology study will include 18 tracheostomized patients ventilated for more than 72 hours. The objective of this study is to compare the effect of three different modalities of SBTs on respiratory effort in tracheostomized patients. The modalities tested are : Pressure Support Ventilation (PSV level 5 cmH2O, PEEP 5 cmH2O), T-piece test and high-flow Oxygen. Each modality is applied in a randomized order, during 30 minutes. During every modality tested, esophageal and gastric pressure, expired CO2, and comfort will be monitored, in addition to standard monitoring. Based on esophageal pressure monitoring, patient's respiratory efforts can be calculated either by esophageal pressure-time product and work of breathing. Pressure generated by inspiratory muscles will also be assessed.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Mechanical Ventilation Complication

Currently open trials in the same condition.

NCT06921655 — Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation · NA · recruiting
NCT07207772 — EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery · NA · recruiting
NCT07182851 — Prevalence of Pain in Mechanically Ventilated Patients in Intensive Care Units · recruiting
NCT06575530 — Sedation Efficacy and Safety of Remazolam Besylate in Ventilated Surgical Critically Ill Patients · Phase 4 · recruiting
NCT06592144 — TESTO-TRIAL: Use of Testosterone in Critically Ill Patients · Phase 4 · active not recruiting

Other Piquilloud Imboden Lise trials

Trials by the same sponsor.

NCT04987398 — Ventilation Weaning Strategies and Correlation to Outcomes in Tracheostomized Patients in the Lausanne ICU · completed
NCT04013698 — Influence of Respiratory Mechanics on Brain-specific Monitoring in Brain-injured Patients · NA · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03856424 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Piquilloud Imboden Lise
Last refreshed: 3 June 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03856424.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing