NCT03850587 is a Phase 2 clinical trial of Celecoxib 200mg in Osteoarthritis, Knee, sponsored by Yooyoung Pharmaceutical Co., Ltd..

Who is sponsoring NCT03850587?

NCT03850587 is sponsored by Yooyoung Pharmaceutical Co., Ltd..

What drugs are being tested in NCT03850587?

Interventions in NCT03850587: Celecoxib 200mg, Tramadol 37.5Mg+ Celecoxib 200mg, Tramadol 75mg+ Celecoxib 200mg, Tramadol 150mg+ Celecoxib 200mg.

What condition does NCT03850587 study?

NCT03850587 studies Osteoarthritis, Knee.

Is NCT03850587 still recruiting?

NCT03850587 is currently completed. Last updated 11 May 2021.

Last reviewed 2021-05-11 · How we verify

NCT03850587

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Clinical Trial of YYC301 for Treatment of Osteoarthritis of the Knee

Completed Phase 2 Last updated 11 May 2021

What this trial tests

Phase 2 trial testing Celecoxib 200mg in Osteoarthritis, Knee in 261 participants. Completed in 7 September 2020.

Timeline

30 August 2018

Primary endpoint
12 May 2020

7 September 2020

Quick facts

Lead sponsor	Yooyoung Pharmaceutical Co., Ltd.
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	261
Start date	30 August 2018
Primary completion	12 May 2020
Estimated completion	7 September 2020
Sites	10 locations across South Korea

Drugs / interventions tested

Celecoxib 200mg
Tramadol 37.5Mg+ Celecoxib 200mg — full drug profile →
Tramadol 75mg+ Celecoxib 200mg — full drug profile →
Tramadol 150mg+ Celecoxib 200mg — full drug profile →

Conditions studied

Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →

Sponsor

Yooyoung Pharmaceutical Co., Ltd. — full company profile →

Who can join

20 and older, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A Multi-center, Double-blinded, Randomized, Active-controlled, Parallel Design, phaseII Study to Investigate the Efficacy and Safety of YYC301 in Subject With Knee Osteoarthritis

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Molecular Classification of Knee Osteoarthritis.
Lv Z, Yang YX, Li J, Fei Y, et al · · 2021 · cited 69× · PMID 34513847 · DOI 10.3389/fcell.2021.725568
Challenges and opportunities of pharmacological interventions for osteoarthritis: A review of current clinical trials and developments.
Vrouwe JPM, Burggraaf J, Kloppenburg M, Stuurman FE. · · 2021 · cited 16× · PMID 36474768 · DOI 10.1016/j.ocarto.2021.100212
Pharmaceutical therapeutics for articular regeneration and restoration: state-of-the-art technology for screening small molecular drugs.
Chen Y, Sun H, Yao X, Yu Y, et al · · 2021 · cited 9× · PMID 34783870 · DOI 10.1007/s00018-021-03983-8

Verify or expand the search:

Other trials of Celecoxib 200mg

Trials testing the same drug.

NCT07246278 — Celecoxib in Parkinson Disease as Adjuvant Therapy · Phase 1, PHASE2 · recruiting
NCT06231758 — Metformin Safety and Efficacy in Osteoarthritis. · Phase 3 · recruiting
NCT05962957 — Role of Pentoxifylline and Celecoxib in Parkinsonism · Phase 2 · completed
NCT05765747 — Effectiveness of Yunnan Baiyao in Improving Fracture Pain · NA · unknown
NCT05434065 — Effects and Mechanisms of Celecoxib on Intracerebral Hemorrhage · Phase 2 · recruiting

Other recruiting trials for Osteoarthritis, Knee

Currently open trials in the same condition.

NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting

Other Yooyoung Pharmaceutical Co., Ltd. trials

Trials by the same sponsor.

NCT07096050 — Post Marketing Clinical Follow up Study of HyaleXo · NA · completed
NCT05362851 — Clinical Trial of YYC301 P3 for Treatment of Osteoarthritis of the Knee · Phase 3 · unknown
NCT05226897 — Clinical Trial to Assess the Efficacy and Safety of YYC405 in Type 2 Diabetes Patients · Phase 3 · unknown
NCT04858308 — Phase 3 Trial to Evaluate the Efficacy and Safety of YYC506. · Phase 3 · unknown
NCT04874129 — Phase 1 to Evaluate the Safety and Pharmacokinetic Characteristics of Fixed-dose Combination of YYC506 · Phase 1 · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03850587 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Yooyoung Pharmaceutical Co., Ltd.
Last refreshed: 11 May 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03850587.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing