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NCT03849911: ProNeCA
EEG and SEP Evaluation for Good and Poor Neurological Prognosis After Cardiac Arrest
trial testing Neurophysiological Prognosis in Neurological Prognosis Cardiac Arrest in 400 participants. Completed in 1 December 2018.
1 June 2018
Quick facts
| Lead sponsor | Azienda Ospedaliero-Universitaria Careggi |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 400 |
| Start date | 1 June 2016 |
| Primary completion | 1 June 2018 |
| Estimated completion | 1 December 2018 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Neurophysiological Prognosis
- Multimodal Prognosis for poor early neurological outcome
Conditions studied
- Neurological Prognosis Cardiac Arrest — all drugs for Neurological Prognosis Cardiac Arrest →
Sponsor
Azienda Ospedaliero-Universitaria Careggi — full company profile →
Who can join
Adults 18 to 90, any sex, with Neurological Prognosis Cardiac Arrest. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Hypoxic-Ischemic-encephalopathy (HIE) is a severe and frequent neurological complication of successful cardiopulmonary-resuscitation after cardiac arrest (CA). Prognosticating neurological outcomes in patients with HIE is challenging and recent guidelines suggest a multimodal approach. Only few studies have analyzed the prognostic power of the association between instrumental tests and, in addition, most of them were monocentric, retrospective and evaluating only poor outcome.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Do changes in SSEP amplitude over time predict the outcome of comatose survivors of cardiac arrest?
Scarpino M, Lolli F, Lanzo G, Carrai R, et al · · 2022 · cited 5× · PMID 36375653 · DOI 10.1016/j.resuscitation.2022.10.025
Verify or expand the search:
- PubMed search for NCT03849911
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03849911 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Azienda Ospedaliero-Universitaria Careggi
- Last refreshed: 30 April 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03849911.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing