NCT03846518 is a NA clinical trial of Hyrax in Malocclusion, sponsored by Pontifícia Universidade Católica de Minas Gerais.

Who is sponsoring NCT03846518?

NCT03846518 is sponsored by Pontifícia Universidade Católica de Minas Gerais.

What drugs are being tested in NCT03846518?

Interventions in NCT03846518: Hyrax, mini Hyrax.

What condition does NCT03846518 study?

NCT03846518 studies Malocclusion, Posterior Crossbite.

Is NCT03846518 still recruiting?

NCT03846518 is currently completed. Last updated 5 March 2020.

Last reviewed 2020-03-05 · How we verify

NCT03846518

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Two Tooth-borne Expanders in Rapid Maxillary Expansion

Completed NA Last updated 5 March 2020

What this trial tests

NA trial testing Hyrax in Malocclusion in 34 participants. Completed in 27 February 2020.

Timeline

1 December 2018

Primary endpoint
18 September 2019

27 February 2020

Quick facts

Lead sponsor	Pontifícia Universidade Católica de Minas Gerais
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	34
Start date	1 December 2018
Primary completion	18 September 2019
Estimated completion	27 February 2020
Sites	1 location across Brazil

Drugs / interventions tested

Hyrax
mini Hyrax

Conditions studied

Malocclusion — all drugs for Malocclusion →
Posterior Crossbite — all drugs for Posterior Crossbite →

Sponsor

Pontifícia Universidade Católica de Minas Gerais

Who can join

Adults 12 to 16, any sex, with Malocclusion or Posterior Crossbite. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will assess the dentoalveolar effects and impact on quality of life of two types of maxillary expanders in orthodontic patients with permanent dentition, from 12 to 16 years old. Half of participants will be treated using the Hyrax expander, while the other half will use the mini Hyrax expander. The null hypothesis is that there is no difference between dentoalveolar effects and impact on quality of life of the two protocols.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Mini Hyrax vs Hyrax expanders in the rapid palatal expansion in adolescents with posterior crossbite: a randomized controlled clinical trial.
Silveira GS, Abreu LG, Palomo JM, da Matta Cid Pinto LS, et al · · 2021 · cited 8× · PMID 34467450 · DOI 10.1186/s40510-021-00365-5

Verify or expand the search:

Other trials of Hyrax

Trials testing the same drug.

NCT06986343 — Impact of Palatal Expansion and Up-Locker Activator on Sleep and Pharyngeal Dimensions in Children · NA · enrolling by invitation

Other recruiting trials for Malocclusion

Currently open trials in the same condition.

NCT05684510 — Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket Therapy · NA · recruiting
NCT07290790 — A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSm · NA · recruiting
NCT06858670 — Effectiveness of Auxiliary Segmental Lingual Appliances in Leveling the Curve of Wilson at Second Molars · NA · recruiting
NCT06536335 — Evaluation of the Perceived Experience of Patients Treated With Aligners With Two Different Timings · NA · recruiting
NCT07094581 — Evaluation of the Effect of Adenoid Hypertrophy on the Masseter Muscle in Children: A Comparative Ultrasonographic Study · recruiting

Other Pontifícia Universidade Católica de Minas Gerais trials

Trials by the same sponsor.

NCT04354116 — MARPE in Patients With Cleft Lip and Palate · NA · unknown
NCT03089996 — Evaluation of Clinical Approaches to Accelerate Orthodontic Tooth Movement · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03846518 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Pontifícia Universidade Católica de Minas Gerais
Last refreshed: 5 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03846518.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing