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NCT03843021
Ventricular Assist Device (VAD) Infection Prevention Survey
trial testing VAD Infection Prevention Survey in Heart Failure in 208 participants. Completed in 23 December 2022.
23 December 2022
Quick facts
| Lead sponsor | University of Michigan |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 208 |
| Start date | 29 May 2019 |
| Primary completion | 23 December 2022 |
| Estimated completion | 23 December 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- VAD Infection Prevention Survey
Conditions studied
- Heart Failure — all drugs for Heart Failure →
- Healthcare Associated Infection — all drugs for Healthcare Associated Infection →
- Ventricular Assist Device — all drugs for Ventricular Assist Device →
Sponsor
University of Michigan
Who can join
18 and older, any sex, with Heart Failure or Healthcare Associated Infection. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Annually, more than 250,000 patients in the U.S. with end-stage heart failure stand to benefit from ventricular assist device (VAD) therapy. 60% of patients develop a healthcare-associated infection (HAI) within 90-days of implantation. The investigators long term goal is to develop and subsequently promote wide-scale adoption of evidence-based HAI prevention practices following durable VAD implantation. This will be done by addressing the following aims: Aim 1. Identify determinants of center-level variability in HAI rates. Aim 2. Develop a comprehensive understanding of barriers and facilitators for achieving low center HAI rates. Aim 3. Develop, iteratively enhance, and disseminate a best practices toolkit for preventing HAIs that accommodates various center contexts. The investigators will use a focused survey of U.S. VAD centers to identify determinants of center variation in 90-day HAI rates: * Process Factors (e.g., intranasal mupirocin), * Provider Factors (e.g., surgeon technique), * Device Factors (e.g., centrifugal vs. axial), * Center Factors (e.g., provider communication). Understanding the barriers and facilitators within individual centers for maximizing adoption of prevention measures would serve as the foundation for targeted improvement strategies. Without this knowledge, evidence-based, action-oriented recommendations will have limited local adoption and ultimately effectiveness in preventing HAIs after VAD implantation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03843021
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03843021 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Michigan
- Last refreshed: 14 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03843021.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing