Last reviewed · How we verify
NCT03842657: C2D
Regional Anticoagulation of Dialysis Circuits With a Calcium-free Citrate-containing Dialysate
Phase 2 trial testing anticoagulation of the dialysis circuit in Hemodialysis Complication in 97 participants. Completed in 13 September 2021.
13 September 2021
Quick facts
| Lead sponsor | University Hospital, Toulouse |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 97 |
| Start date | 5 July 2019 |
| Primary completion | 13 September 2021 |
| Estimated completion | 13 September 2021 |
| Sites | 5 locations across France |
Drugs / interventions tested
- anticoagulation of the dialysis circuit
Conditions studied
- Hemodialysis Complication — all drugs for Hemodialysis Complication →
- Bleeding — all drugs for Bleeding →
Sponsor
University Hospital, Toulouse
Who can join
18 and older, any sex, with Hemodialysis Complication or Bleeding. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Critically ill patients have a high risk of bleeding but also require prolonged intermittent dialysis. Thus, a heparin-free easy-to-use alternative type of anticoagulation within the dialysis circuit is required. In a non-comparative study, heparin-free regional citrate anticoagulation of the dialysis circuit using a calcium-free citrate-containing dialysate, with calcium reinjected according to ionic dialysance, was considered as safe and efficient. The aim of this study is to confirm the superiority of this approach compared to a anticoagulation based on heparin-grafted membrane.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A randomized crossover trial of regional anticoagulation modalities for intermittent haemodialysis.
Faguer S, Serre JE, Brusq C, Bongard V, et al · · 2025 · cited 1× · PMID 38977911 · DOI 10.1093/ndt/gfae155
Verify or expand the search:
- PubMed search for NCT03842657
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03842657 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Toulouse
- Last refreshed: 15 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03842657.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing