Adults 26 to 58, any sex, with Cardiovascular Diseases. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Change in Hippocampal VolumePrimary· Baseline & 12 months
Magnetic Resonance Imaging (MRI) will be used to measure the structure of the brain. Segmentation algorithms applied to structural MRI images will be used to compute the volume of the hippocampus in particular, which will be evaluated for change over the course of the trial.
Group
Value
95% CI
Aerobic Exercise Group
-15.4
-79.3 – 48.4
Physical Activity & Health Information Group
-49.9
-112.8 – 13
Change in Systolic Blood Pressure Responses to Behavioral TasksSecondary· Baseline & 12 months
Average systolic blood pressure will be computed during a resting baseline period and during the performance of two behavioral tasks, (1) a Stroop color-word interference task and (2) a multi-source interference task. Mean baseline levels of systolic blood pressure will be subtracted from mean levels averaged across the two tasks to compute response scores, and changes in task-response scores will be evaluated over the course of the trial.
Group
Value
95% CI
Aerobic Exercise Group
-0.932
-3.7 – 1.836
Physical Activity & Health Information Group
-3.519
-6.2 – -0.835
Change in Heart Rate Variability (HRV)Secondary· Baseline & 12 months
Heart rate variability will be computed from inter-beat intervals derived from electrocardiographic recordings while participants rest in the seated position. Average heart rate variability values from the recording period will be assessed for their change over the trial. Here, we report the natural log-transformed variance of high-frequency (HF) heart rate variability.
Group
Value
95% CI
Aerobic Exercise Group
0.0022
-0.257 – 0.261
Physical Activity & Health Information Group
-0.2035
-0.472 – 0.065
Adverse events — posted to ClinicalTrials.gov
Time frame: 1 year.
Reporting threshold: 0%.
Adverse-event reports describe events observed during the trial — not all are caused by the drug.
eBACH is a randomized intervention to determine the effects of aerobic exercise on brain structure and function, as well as to determine how exercise-induced training effects relate to cardiovascular function via related brain changes.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
NCT07504887 — Effects of Aerobic Exercise in Rheumatoid Arthritis
· NA
· not yet recruiting
NCT03557502 — Heat Therapy Versus Exercise Training in Hypertension
· NA
· completed
NCT03491566 — Effects of Two Different Exercises on Cognition
· NA
· completed
NCT04127448 — Exergaming Versus Aerobic Exercises on Mild Cognitive Impairment
· NA
· completed
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Pittsburgh
Last refreshed: 24 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03841669.