Last reviewed · How we verify
NCT03838549: MRIMOP
Pre Pectoral Implant for Immediate Breast Reconstruction Using Single Port Endoscopy in Prophylactic Indication
NA trial testing Prophylactic mastectomy with immediate breast reconstruction in Genetic Predisposition in 20 participants. Completed in 26 September 2025.
26 September 2025
Quick facts
| Lead sponsor | University Hospital, Montpellier |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 26 April 2019 |
| Primary completion | 26 September 2025 |
| Estimated completion | 26 September 2025 |
| Sites | 1 location across France |
Drugs / interventions tested
- Prophylactic mastectomy with immediate breast reconstruction
Conditions studied
- Genetic Predisposition — all drugs for Genetic Predisposition →
- Breast Cancer — all drugs for Breast Cancer →
Sponsor
University Hospital, Montpellier
Who can join
20 and older, female only, with Genetic Predisposition or Breast Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Implant-based reconstruction is currently the most common choice for mastectomy reconstruction. Whatever the choice of mastectomy incision, a scar remains on or near the breast volume. Current techniques involve partial or total coverage of the implant with the pectoralis major muscle, to prevent exposure or infection. The muscle dissection technique applied has functional and cosmetic consequences. In this study, an endoscopic approach will be evaluated. This new surgical technique, using a single-port endoscopic way, will put the scar is in the axillary area, away from the breast. The hypothesis is that this delocalized scar potentially reduces the risk of exposure and allows placement of the implant in the subcutaneous space, with no manipulation of the pectoralis major muscle.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Endoscopic prophylactic nipple-sparing mastectomy: First French survey of 10 patients.
Rathat G, Chaumette M, Fontaine V, Rebel L, et al · · 2025 · cited 2× · PMID 39393530 · DOI 10.1016/j.jogoh.2024.102862
Verify or expand the search:
- PubMed search for NCT03838549
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University Hospital, Montpellier trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03838549 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Montpellier
- Last refreshed: 16 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03838549.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing