Detection and Amelioration of Gamma Oscillation Abnormalities in Blast-Related Brain Injury (DAGABBI)

NCT03836976 NA RECRUITING

Combat Veterans of post-9/11 conflicts have experienced serious cognitive and emotional problems resulting from exposure to blasts. Recent work suggests that a critical factor influencing the consequences of blast exposure is distance from the blast, rather than the presence or absence of concussion symptoms. Exposure to blasts from a distance of \<10 m has been associated with significantly greater cognitive and neural problems than exposure to blasts from \>10 m. So far, the effects of blast-related brain injury on the brain are poorly understood, as to date the effects of blast exposure have received little research focus. The investigators propose to use oscillations in the gamma band (30-100 Hz) of the electroencephalogram (EEG; brain waves) to detect and remediate neural circuit dysfunction related to blast injury in Veterans. If successful, this project could lead to new approaches to detect and remediate the effects of blast exposure on Veterans and aid in their functional recovery.

Details

Lead sponsor	VA Office of Research and Development
Phase	NA
Status	RECRUITING
Enrolment	50
Start date	Mon Dec 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Fri Jun 30 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• mTBI

Interventions

• Auditory gamma sensory stimulation

Countries

United States