NCT03835312 is a NA clinical trial of Sequential transplantation in Diabetes Mellitus, Type 1, sponsored by Children's Hospital of Fudan University.

Who is sponsoring NCT03835312?

NCT03835312 is sponsored by Children's Hospital of Fudan University.

What drugs are being tested in NCT03835312?

Interventions in NCT03835312: Sequential transplantation.

What condition does NCT03835312 study?

NCT03835312 studies Diabetes Mellitus, Type 1, Immunologic Deficiency Syndromes.

Is NCT03835312 still recruiting?

NCT03835312 is currently recruiting now. Last updated 17 March 2026.

Last reviewed 2026-03-17 · How we verify

NCT03835312

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Sequential Transplantation of UCBSCs and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency T1DM

Recruiting now NA Last updated 17 March 2026

What this trial tests

NA trial testing Sequential transplantation in Diabetes Mellitus, Type 1 in 50 participants. Currently enrolling.

Timeline

20 February 2019

Primary endpoint
31 December 2028

31 December 2030

Quick facts

Lead sponsor	Children's Hospital of Fudan University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	50
Start date	20 February 2019
Primary completion	31 December 2028
Estimated completion	31 December 2030
Sites	1 location across China

Drugs / interventions tested

Sequential transplantation

Conditions studied

Diabetes Mellitus, Type 1 — all drugs for Diabetes Mellitus, Type 1 →
Immunologic Deficiency Syndromes — all drugs for Immunologic Deficiency Syndromes →

Sponsor

Children's Hospital of Fudan University

Who can join

Under 18, any sex, with Diabetes Mellitus, Type 1 or Immunologic Deficiency Syndromes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study evaluates the efficacy of sequential transplantation of umbilical cord blood stem cells and islet cells in children with monogenic immunodeficiency type 1 diabetes mellitus. Umbilical cord blood stem cell transplantation will be performed first. Children with stable immune reconstruction will than receive islet cell transplantation.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges.
Silva IBB, Kimura CH, Colantoni VP, Sogayar MC. · · 2022 · cited 53× · PMID 35840987 · DOI 10.1186/s13287-022-02977-y
Fresh Umbilical Cord Blood-A Source of Multipotent Stem Cells, Collection, Banking, Cryopreservation, and Ethical Concerns.
Devi S, Bongale AM, Tefera MA, Dixit P, et al · · 2023 · cited 17× · PMID 37763198 · DOI 10.3390/life13091794
Advances in hematopoietic stem cell transplantation for autoimmune diseases.
Xu Y, Wang X, Hu Z, Huang R, et al · · 2024 · cited 4× · PMID 39492896 · DOI 10.1016/j.heliyon.2024.e39302

Verify or expand the search:

Other recruiting trials for Diabetes Mellitus, Type 1

Currently open trials in the same condition.

NCT07325461 — Feasibility Study of Extended Wear Insulin Infusion Set Options During Home Use in People With Type 1 Diabetes · NA · recruiting
NCT07305805 — A Research Study of a New Medicine NNC0363-1063 in Participants With Type 1 Diabetes · Phase 1 · recruiting
NCT06282055 — Trajectories in Insulin Sensitivity Across MEnstrual cycleS in Women With Type 1 Diabetes · recruiting
NCT06325202 — Closed Loop and Education for Hypoglycemia Awareness Restoration · NA · recruiting
NCT07160816 — A Research Study to See How Insulin Icodec Helps People With Type 1 Diabetes Control Their Blood Sugar · recruiting

Other Children's Hospital of Fudan University trials

Trials by the same sponsor.

NCT04955821 — Early Identification of Pathogens in Children With Respiratory Tract Infection by Mechanical Ventilation Using mNGS · not yet recruiting
NCT05862688 — A Cohort Study on Anti-microbial Stewardship in PICU · not yet recruiting
NCT05595239 — Blood Purification in Septic Children · NA · not yet recruiting
NCT07325903 — Research of Integrated Traditional Chinese and Western Medicine on Precocious Puberty · EARLY_PHASE1 · not yet recruiting
NCT07141615 — Clinical Observation of Qingwei Huazhuo Decoction (Product: Jinsaiyu) in Improving Children With Precocious Puberty of P · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03835312 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Children's Hospital of Fudan University
Last refreshed: 17 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03835312.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing