NCT03833973: SuPpOrt

Safety and Prevention of OveRTraining

Status unknown Last updated 27 December 2019

What this trial tests

trial testing Overtraining Monitoring in Overtraining Syndrome in 100 participants. Status unknown.

Timeline

1 January 2018

Primary endpoint
1 June 2020

30 July 2020

Quick facts

Lead sponsor	University of Thessaly
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	100
Start date	1 January 2018
Primary completion	1 June 2020
Estimated completion	30 July 2020
Sites	1 location across Greece

Drugs / interventions tested

• Overtraining Monitoring

Conditions studied

• Overtraining Syndrome — all drugs for Overtraining Syndrome →

Sponsor

University of Thessaly

Who can join

Adults 15 to 40, any sex, with Overtraining Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Athletic training aims to increase and improve physical performance that is achieved through training overload combined with periods of rest and recovery. Overtraining syndrome (OTS) is associated with an imbalance between training and recovery. The symptoms associated with OTS vary between individuals and may reflect parasympathetic and/or sympathetic nervous system alterations as well as endocrine irregularities. The prevalence is not known, but it is usually reported among endurance athletes, such as cyclists, distance runners and triathletes. It appears that OTS represents a systemic inflammatory process with diffuse effects on the neurohormonal axis affecting host immunology and mood. Previous works, showed that cell-free DNA (cf-DNA) is correlated with the severity of excessive exercise-induced inflammation as well as with trauma and stroke severity suggesting that it might be used as a potential clinical marker for athletes with overtraining syndrome. Oxidative stress indices can be determined non-invasively and may reflect inflammatory responses after training suggesting that they could be used as clinical markers for the diagnosis of OTS. However, there are no available biomarkers to aid towards the diagnosis and/or prevention of OTS, except that of the persistence of unexplained underperformance despite an extensive recovery of the athlete. Therefore, the purpose of this study is to evaluate the potential of cf-DNA and selected oxidative stress variables as diagnostic biomarkers of OTS.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Current Trends in Cell-Free DNA Applications. Scoping Review of Clinical Trials.
   Stawski R, Stec-Martyna E, Chmielecki A, Nowak D, et al · · 2021 · cited 20× · PMID 34571783 · DOI 10.3390/biology10090906