Last reviewed · How we verify
NCT03833297: HePATOX
Monitoring the HePAtological TOXicity of Drugs (HePATOX)
trial testing Drugs inducing hepatological toxicity in Liver Diseases in 1,000 participants. Completed in 4 April 2023.
4 February 2020
Quick facts
| Lead sponsor | Groupe Hospitalier Pitie-Salpetriere |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,000 |
| Start date | 4 February 2019 |
| Primary completion | 4 February 2020 |
| Estimated completion | 4 April 2023 |
| Sites | 1 location across France |
Drugs / interventions tested
- Drugs inducing hepatological toxicity — full drug profile →
Conditions studied
- Liver Diseases — all drugs for Liver Diseases →
- Liver Dysfunction — all drugs for Liver Dysfunction →
- Liver Failure — all drugs for Liver Failure →
- Hepatotoxicity — all drugs for Hepatotoxicity →
Sponsor
Groupe Hospitalier Pitie-Salpetriere
Who can join
18 and older, any sex, with Liver Diseases or Liver Dysfunction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Several drugs and chemotherapies seem to have an impact on the hepatological system. This study investigates reports of hepatological toxicities, including the International classification of disease ICD-10 for treatments in the World Health Organization (WHO) global Individual Case Safety Report (ICSR) database (VigiBase).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Characterization of auto-immune hepatitis associated with the use of anti-TNFα agents: An analysis of 389 cases in VigiBase.
Vollmer O, Felten R, Mertz P, Lebrun-Vignes B, et al · · 2020 · cited 24× · PMID 31917266 · DOI 10.1016/j.autrev.2020.102460
Verify or expand the search:
- PubMed search for NCT03833297
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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- NCT07053488 — CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection · Phase 1, PHASE2 · recruiting
Other Groupe Hospitalier Pitie-Salpetriere trials
Trials by the same sponsor.
- NCT06515678 — Impact of Antihypertensive Therapy on Recurrence Risk of Ovarian Cancer for Bevacizumab-associated Hypertension · active not recruiting
- NCT05934214 — EXploring Immune-related Adverse Events of Immune checkpoinT Inhibitors Using VigiBase, the WHO Pharmacovigilance Databa · completed
- NCT05819736 — Pharmacokinetics Study Of Rivaroxaban and Apixaban in Cancer Patients · unknown
- NCT04320017 — Joint Use of Electrocardiogram and Transthoracic Echocardiography With Other Clinico-biological Parameters in an Observa · completed
- NCT04314817 — Adverse Events Related to Treatments Used Against Coronavirus Disease 2019 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03833297 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Groupe Hospitalier Pitie-Salpetriere
- Last refreshed: 5 April 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03833297.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing