PErsonalized Genomics for Prenatal Abnormalities Screening USing Maternal Blood (PEGASUS-2)

NCT03831256 NA ACTIVE_NOT_RECRUITING

This project aims to provide high- quality evidence to inform decisions by health care organisations about using first-tier non-invasive prenatal screening (NIPS) to replace traditional screening tests for trisomy 21, and potentially to screen for other fetal chromosome anomalies. We will compare the current screening approach of second-tier NIPS with the use of first-tier NIPS in a large cohort of pregnant women.

Details

Lead sponsor	CHU de Quebec-Universite Laval
Phase	NA
Status	ACTIVE_NOT_RECRUITING
Enrolment	7849
Start date	Mon Jan 13 2020 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Mon Jun 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Prenatal Disorder
• Aneuploidy

Interventions

• Traditional integrated prenatal screening
• Second-tier Non-invasive prenatal screening (NIPS)
• First-tier Non-invasive prenatal screening (NIPS)
• Invasive prenatal testing for fetal aneuploidy

Countries

Canada