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NCT03824223
'Fitness To Fly' Tests In Children With Type II Respiratory Failure
NA trial testing Hypoxic challenge test in Neuromuscular Diseases in 20 participants. Completed in 31 August 2021.
31 August 2021
Quick facts
| Lead sponsor | Great Ormond Street Hospital for Children NHS Foundation Trust |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | other |
| Enrollment | 20 |
| Start date | 1 February 2019 |
| Primary completion | 31 August 2021 |
| Estimated completion | 31 August 2021 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Hypoxic challenge test
Conditions studied
- Neuromuscular Diseases — all drugs for Neuromuscular Diseases →
- Central Hypoventilation — all drugs for Central Hypoventilation →
Sponsor
Great Ormond Street Hospital for Children NHS Foundation Trust
Who can join
Adults 0 to 18, any sex, with Neuromuscular Diseases or Central Hypoventilation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The conventional hypoxic challenge test might not predict 'fitness-to-fly' equally well in all patients. Patients at risk of hypercapnia with supplemental oxygen are not well studied. Th investigators will study children who have either neuromuscular weakness or central hypoventilation and who require nocturnal or intermittent daytime ventilator support. The study also aims to assess feasibility of a randomised controlled trial (RCT) comparing the standard hypoxic standard test to a modified test designed to better suit children with type two respiratory failure.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03824223
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Other Great Ormond Street Hospital for Children NHS Foundation Trust trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03824223 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Great Ormond Street Hospital for Children NHS Foundation Trust
- Last refreshed: 8 December 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03824223.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing