NCT03823144 is a NA clinical trial of Diagnostic Microscopy in Solid Tumor, Adult, sponsored by Mayo Clinic.

Who is sponsoring NCT03823144?

NCT03823144 is sponsored by Mayo Clinic.

What drugs are being tested in NCT03823144?

Interventions in NCT03823144: Diagnostic Microscopy, Fluorescein Sodium Injection.

What condition does NCT03823144 study?

NCT03823144 studies Solid Tumor, Adult, Clinical Stage IV Gastric Cancer AJCC v8, Malignant Solid Neoplasm, Metastatic Colorectal Carcinoma, Metastatic Gastric Carcinoma, Metastatic Primary Malignant Brain Neoplasm, Metastatic Sarcoma, Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8, Resectable Colorectal Carcinoma, Resectable Liver and Intrahepatic Bile Duct Carcinoma, Resectable Pancreatic Carcinoma, Resectable Sarcoma, Stage IV Colorectal Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Malignant Brain Neoplasm, Metastatic Breast Carcinoma, Metastatic Liver Carcinoma, Metastatic Pancreatic Carcinoma, Resectable Brain Neoplasm, Resectable Breast Carcinoma, Resectable Gastric Carcinoma, Stage IV Hepatocellular Carcinoma AJCC v8, Stage IV Pancreatic Cancer AJCC v8.

Is NCT03823144 still recruiting?

NCT03823144 is currently recruiting now. Last updated 11 December 2025.

Last reviewed 2025-12-11 · How we verify

NCT03823144

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intravital Microscopy in Human Solid Tumors

Recruiting now NA Last updated 11 December 2025

What this trial tests

NA trial testing Diagnostic Microscopy in Solid Tumor, Adult in 85 participants. Currently enrolling.

Timeline

28 February 2019

Primary endpoint
30 September 2026

30 September 2026

Quick facts

Lead sponsor	Mayo Clinic
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	85
Start date	28 February 2019
Primary completion	30 September 2026
Estimated completion	30 September 2026
Sites	1 location across United States

Drugs / interventions tested

Diagnostic Microscopy
Fluorescein Sodium Injection

Conditions studied

Solid Tumor, Adult — all drugs for Solid Tumor, Adult →
Clinical Stage IV Gastric Cancer AJCC v8 — all drugs for Clinical Stage IV Gastric Cancer AJCC v8 →
Malignant Solid Neoplasm — all drugs for Malignant Solid Neoplasm →
Metastatic Colorectal Carcinoma — all drugs for Metastatic Colorectal Carcinoma →

Sponsor

Mayo Clinic

Who can join

18 and older, any sex, with Solid Tumor, Adult or Clinical Stage IV Gastric Cancer AJCC v8. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will investigate the tumor-associated vasculature of patients with solid tumors. The investigators will use a technology known as intravital microscopy (IVM) in order to visualize in real-time the vessels associated with solid tumors. The IVM observations may determine if an individual patient's tumor vessels would be amenable to receiving systemic therapy, based on the functionality of the vessels.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Dynamic control of tumor vasculature improves antitumor responses in a regional model of melanoma.
Gabriel EM, Kim M, Fisher DT, Powers C, et al · · 2020 · cited 10× · PMID 32764623 · DOI 10.1038/s41598-020-70233-5
A pilot trial of intravital microscopy in the study of the tumor vasculature of patients with peritoneal carcinomatosis.
Gabriel EM, Kim M, Fisher DT, Mangum C, et al · · 2021 · cited 8× · PMID 33654117 · DOI 10.1038/s41598-021-84430-3
Intravital Microscopy (IVM) in Human Solid Tumors: Novel Protocol to Examine Tumor-Associated Vessels.
Trumbull DA, Lemini R, Bagaria SP, Elli EF, et al · · 2020 · cited 3× · PMID 33034295 · DOI 10.2196/15677
Human intravital microscopy in the study of sarcomas: an early trial of feasibility.
Gabriel EM, Sukniam K, Popp K, Bagaria SP. · · 2023 · cited 2× · PMID 37124504 · DOI 10.3389/fonc.2023.1151255
93096 Does gender matter? Gender differences in the relationship between resting-state functional connectivity and emotion regulation in alcohol use disorder.
Nyoi K, Koithan E, Hendrickson T, Verdoorn H, et al · · 2021
77286 Intravital microscopy in the study of the tumor vasculature of patients with peritoneal carcinomatosis
Gabriel E, Kim M, Fisher D, Mangum C, et al · · 2021
70400 Collaborative Care for Opioid Dependence And Pain (CCODAP): A Pilot Randomized Control Trial of an Opioid Tapering Intervention
Bushey M, Kroenke K. · · 2021
73936 Developing a Patient-Rated Outcome Measure of Alcohol and Drug Craving: A Systematic Review
Haeny A, Morean M, DeMartini K, Funaro M, et al · · 2021

Verify or expand the search:

Other trials of Diagnostic Microscopy

Trials testing the same drug.

NCT03297489 — Intravital Microscopy in Evaluating Patients With Primary Peritoneal, Fallopian Tube, or Stage IA-IV Ovarian Cancer · EARLY_PHASE1 · completed
NCT02857374 — Intravital Microscopy in Identifying Tumor Vessels in Patients With Stage IB-IIIC Melanoma Undergoing Sentinel Lymph Nod · NA · completed
NCT01886235 — Intravital Microscopy for Identifying Tumor Vessels in Patients With Stage IA-IV Melanoma That is Being Removed by Surge · NA · completed
NCT00542373 — Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for De · NA · active not recruiting

Other recruiting trials for Solid Tumor, Adult

Currently open trials in the same condition.

NCT07139990 — Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM) · Phase 1 · recruiting
NCT06398418 — R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients · Phase 1 · recruiting
NCT06682793 — A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumor · Phase 1, PHASE2 · recruiting
NCT07137195 — Clinical Trial of the Safety and Efficacy of IBA Proton Therapy System PROTEUS® PLUS (Hebei) · NA · active not recruiting
NCT06714617 — Evaluate BL-M17D1 in Patients w/HER2-Expressing/Mutant Advanced or Metastatic Solid Tumors · Phase 1 · active not recruiting

Other Mayo Clinic trials

Trials by the same sponsor.

NCT07126548 — A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men · NA · not yet recruiting
NCT07221656 — Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration · not yet recruiting
NCT06891001 — The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, · NA · not yet recruiting
NCT07169799 — Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE) · NA · recruiting
NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03823144 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
Last refreshed: 11 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03823144.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing