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DNA-mutation Analysis in Cyst Fluid of Suspected Intraductal Papillary Mucinous Neoplasia of the Pancreas
Diagnostic tools are needed to identify mucinous cysts for further evaluation or follow-up respectively to identify cysts with HGD or invasive cancer at an early stage for surgical resection. Molecular genetic analysis of pancreatic cyst fluid is a new but rapidly evolving method to identify KRAS/GNAS oncogenic driver mutations in mucinous cysts and to identify tumour suppressor gene mutations which are involved in advanced cysts with HGD or carcinoma. The ongoing ZYSTEUS-study tries to implement DNA mutation analysis by Next Generation Sequencing in the diagnostic algorithm of pancreas cyst evaluation. The first aim is to distinguish mucinous from non-mucinous cysts. The second aim is to define relevant tumour suppressor gene mutations which are relevant to distinguish between LGD and HGD/carcinoma in mucinous cysts.
Details
| Lead sponsor | Theresienkrankenhaus und St. Hedwig-Klinik GmbH |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 150 |
| Start date | Mon Jan 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Thu Dec 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Pancreas Cyst
Interventions
- Next Generation Sequencing
- CEA and lipase
- Cytology
- Histology of resected pancreas cyst
Countries
Germany