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NCT03817996: HIDRATE
Fluid Responsiveness in HFNC Patients
trial testing Fluid challenge in Respiratory Insufficiency in 30 participants. Completed in 30 April 2019.
30 March 2019
Quick facts
| Lead sponsor | Hospital Universitari Vall d'Hebron Research Institute |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 1 January 2017 |
| Primary completion | 30 March 2019 |
| Estimated completion | 30 April 2019 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Fluid challenge — full drug profile →
Conditions studied
- Respiratory Insufficiency — all drugs for Respiratory Insufficiency →
- Shock, Septic — all drugs for Shock, Septic →
- Sepsis — all drugs for Sepsis →
Sponsor
Hospital Universitari Vall d'Hebron Research Institute
Who can join
18 and older, any sex, with Respiratory Insufficiency or Shock, Septic. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The plethysmographic variation index (PVi) is a measure of the respiratory-induced variations in the plethysmographic waveform. Interestingly, in mechanically ventilated patients and under certain conditions, PVi may reflect fluid responsiveness (FR). Patients treated with high flow nasal cannula (HFNC), which has been described as a useful supportive therapy in spontaneously breathing patients with respiratory failure, may present the same hemodynamic changes, measured by transthoracic echocardiography, as those patients who are mechanically ventilated (MV). The hypothesis of the present study is that the PVi may predict FR in HFNC patients and, therefore, the objective is to investigate whether the PVi can predict FR in patients treated with HFNC.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03817996
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT04934345 — EFFECT OF VASOPRESSORS ON FLUID CHALLENGE PERSISTENCE AN OBSERVATIONAL STUDY IN PATIENTS UNDERGOING LAPAROTOMY. · unknown
- NCT04693923 — Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients · NA · unknown
Other recruiting trials for Respiratory Insufficiency
Currently open trials in the same condition.
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Other Hospital Universitari Vall d'Hebron Research Institute trials
Trials by the same sponsor.
- NCT07519343 — Migraine and Endometriosis: The FEMININE Study · not yet recruiting
- NCT07509541 — Hemodynamic and Respiratory Instability During Percutaneous Pulmonary Thrombectomy · not yet recruiting
- NCT07456280 — Evaluation of the Non-invasive Electrocardiographic Monitoring Strategy Associated With Early Discharge in Patients With · NA · not yet recruiting
- NCT07281911 — Early Biological and Mechanical Profiling in Sepsis-Associated ARDS · not yet recruiting
- NCT07430501 — Using Digital Twin Technology and Clinical Decision Support Systems to Improve the Early Detection, Personalised Treatme · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03817996 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Universitari Vall d'Hebron Research Institute
- Last refreshed: 13 August 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03817996.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing