NCT03816579: MAPP

A Meal-based Comparison of Protein Quality, Complementary Proteins and Muscle Anabolism

Completed NA Last updated 29 April 2021

What this trial tests

NA trial testing PRO-A in Protein in 23 participants. Completed in 21 January 2021.

Timeline

26 March 2019

Primary endpoint
21 January 2021

21 January 2021

Quick facts

Lead sponsor	The University of Texas Medical Branch, Galveston
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	other
Enrollment	23
Start date	26 March 2019
Primary completion	21 January 2021
Estimated completion	21 January 2021
Sites	1 location across United States

Drugs / interventions tested

• PRO-A
• PRO-B
• PRO-C

Conditions studied

• Protein — all drugs for Protein →
• Diet — all drugs for Diet →
• Skeletal Muscle — all drugs for Skeletal Muscle →

Sponsor

The University of Texas Medical Branch, Galveston

Who can join

Adults 45 to 60, any sex, with Protein or Diet. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To highlight the importance of protein quality rather than the total protein content of a meal, the investigators will demonstrate that unlike high quality proteins, a single meal containing 30 g of an incomplete protein source does not stimulate skeletal muscle protein synthesis. Secondly, the investigators will directly challenge a prevalent, but untested, assertion that has the potential to negatively impact health. The goal is to demonstrate that complementary plant-proteins (i.e., two or more incomplete protein sources) must be consumed at the same meal to stimulate protein synthesis.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Meals Containing Equivalent Total Protein from Foods Providing Complete, Complementary, or Incomplete Essential Amino Acid Profiles do not Differentially Affect 24-h Skeletal Muscle Protein Synthesis in Healthy, Middle-Aged Women.
   Arentson-Lantz EJ, Von Ruff Z, Connolly G, Albano F, et al · · 2024 · cited 10× · PMID 39396760 · DOI 10.1016/j.tjnut.2024.10.010