NCT03814343 (amphotericin) is a Phase 4 clinical trial of amphotericin B in 30% DMSO in Fungal Infection, sponsored by Mahidol University.

Who is sponsoring NCT03814343?

NCT03814343 is sponsored by Mahidol University.

What drugs are being tested in NCT03814343?

Interventions in NCT03814343: amphotericin B in 30% DMSO, 30% DMSO.

What condition does NCT03814343 study?

NCT03814343 studies Fungal Infection, Onychomycosis, Fungus, Nail.

Is NCT03814343 still recruiting?

NCT03814343 is currently completed. Last updated 28 September 2021.

Last reviewed 2021-09-28 · How we verify

NCT03814343: amphotericin

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Topical Amphotericin B in 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis

Completed Phase 4 Last updated 28 September 2021

What this trial tests

Phase 4 trial testing amphotericin B in 30% DMSO in Fungal Infection in 19 participants. Completed in 30 November 2020.

Timeline

15 January 2019

Primary endpoint
15 November 2020

30 November 2020

Quick facts

Lead sponsor	Mahidol University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	19
Start date	15 January 2019
Primary completion	15 November 2020
Estimated completion	30 November 2020
Sites	1 location across Thailand

Drugs / interventions tested

amphotericin B in 30% DMSO — full drug profile →
30% DMSO — full drug profile →

Conditions studied

Fungal Infection — all drugs for Fungal Infection →
Onychomycosis — all drugs for Onychomycosis →
Fungus, Nail — all drugs for Fungus, Nail →

Sponsor

Mahidol University

Who can join

18 and older, any sex, with Fungal Infection or Onychomycosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The randomized control trial study aimed to evaluate effectiveness and safety of amphotericin B in 30% DMSO solution comparing with 30% DMSO solution in NDMs onychomycosis treatment.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy.
Faustino C, Pinheiro L. · · 2020 · cited 113× · PMID 31906268 · DOI 10.3390/pharmaceutics12010029
Topical and device-based treatments for fungal infections of the toenails.
Foley K, Gupta AK, Versteeg S, Mays R, et al · · 2020 · cited 29× · PMID 31978269 · DOI 10.1002/14651858.cd012093.pub2
Novel and Investigational Treatments for Onychomycosis.
Gregoriou S, Kyriazopoulou M, Tsiogka A, Rigopoulos D. · · 2022 · cited 9× · PMID 36294644 · DOI 10.3390/jof8101079
Lipid-based nanoformulations in onychomycosis therapy: addressing challenges of current therapies and advancing treatment.
Prajapati SK, Jain A, Bajpai M. · · 2025 · cited 5× · PMID 40070389 · DOI 10.1039/d5ra00387c

Verify or expand the search:

Other recruiting trials for Fungal Infection

Currently open trials in the same condition.

NCT07238114 — Liver Cirrhosis Patients With Invasive Pulmonary Aspergillosis: in Depth Understanding Clinical Host Risk Factors · active not recruiting
NCT06510699 — Pharmacogenomics for Better Treatment of Fungal Infections Clinical Trial · Phase 2 · recruiting
NCT05814432 — Efficacy and Safety of High-dose Liposomal Amphotericin B for Disseminated Histoplasmosis in AIDS · Phase 3 · recruiting
NCT03717623 — Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants · Phase 4 · recruiting
NCT03828773 — PTX3-targeted Antifungal Prophylaxis · NA · recruiting

Other Mahidol University trials

Trials by the same sponsor.

NCT07568496 — Greater Occipital Nerve Block for Migraine With Medication Overuse Headache · NA · not yet recruiting
NCT07407400 — Lemborexant for Sleep and Delirium Prevention in Elderly ICU Patients · Phase 4 · not yet recruiting
NCT07378501 — Thai Version of the Pediatric Quality of Recovery Score (PedSQoR): Translation and Psychometric Validation Study · not yet recruiting
NCT07438301 — Septic Shock Hemodynamic Respond to Volume Resuscitation Versus Vasopressor Administration · not yet recruiting
NCT07390006 — Enabling Patient-Reported Outcomes Through Innovative Care - ACS (EPIC-ACS) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03814343 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mahidol University
Last refreshed: 28 September 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03814343.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing