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NCT03813368
Whipples Resection in Octogenarians
trial testing Whipples pancreatico-duodenectomy in Pancreatic Cancer in 500 participants. Completed in 1 July 2019.
1 May 2019
Quick facts
| Lead sponsor | University of Edinburgh |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 500 |
| Start date | 20 February 2019 |
| Primary completion | 1 May 2019 |
| Estimated completion | 1 July 2019 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Whipples pancreatico-duodenectomy
Conditions studied
- Pancreatic Cancer — all drugs for Pancreatic Cancer →
Sponsor
University of Edinburgh
Who can join
18 and older, any sex, with Pancreatic Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Whipples resection is an operation that has a burden of high morbidity and mortality. It is performed for a variety of disorders of the pancreas, duodenum and ampulla. The most common indication is pancreatic ductal adenocarcinoma which has a poor long term outcome even when curative surgery has been performed. Short and long term outcomes however, have improved recently and the indications for curative resection have been increasingly extended, including operating on those that previously may have been considered too old to benefit from curative resection. Little is known about the benefit of performing this procedure in the oldest patients. Performing Whipples resection in patients over the age of 70 has been reported and has been shown to result in satisfactory perioperative results with comparable long term outcomes to those under 70. However the benefit of performing the same procedure in the over 80 age group is less well reported and consistently presents a challenging decision for the clinician.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Meta-Research in Geriatric Surgery: Improving the Quality of Surgical Evidence for Older Persons in a Multidimensional-Scale Research Field.
Lozada-Martinez ID, Hernandez-Paez DA, Palacios Velasco I, Martinez Guevara D, et al · · 2024 · cited 3× · PMID 39336933 · DOI 10.3390/jcm13185441
Verify or expand the search:
- PubMed search for NCT03813368
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03813368 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Edinburgh
- Last refreshed: 13 June 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03813368.
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