NCT03812315 is a Phase 2 clinical trial of Propolis chewing gum in Early Childhood Caries, sponsored by Nourhan M.Aly.

Who is sponsoring NCT03812315?

NCT03812315 is sponsored by Nourhan M.Aly.

What drugs are being tested in NCT03812315?

Interventions in NCT03812315: Propolis chewing gum, Propolis mouthwash.

What condition does NCT03812315 study?

NCT03812315 studies Early Childhood Caries.

Is NCT03812315 still recruiting?

NCT03812315 is currently completed. Last updated 25 February 2019.

Last reviewed 2019-02-25 · How we verify

NCT03812315

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Antimicrobial Effect OF Propolis Administrated Through Two Different Vehicles In High Caries Risk Children

Completed Phase 2 Last updated 25 February 2019

What this trial tests

Phase 2 trial testing Propolis chewing gum in Early Childhood Caries in 60 participants. Completed in 20 February 2019.

Timeline

20 December 2017

Primary endpoint
10 February 2019

20 February 2019

Quick facts

Lead sponsor	Nourhan M.Aly
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	60
Start date	20 December 2017
Primary completion	10 February 2019
Estimated completion	20 February 2019
Sites	1 location across Egypt

Drugs / interventions tested

Propolis chewing gum
Propolis mouthwash — full drug profile →

Conditions studied

Early Childhood Caries — all drugs for Early Childhood Caries →

Sponsor

Nourhan M.Aly — full company profile →

Who can join

Adults 6 to 8, any sex, with Early Childhood Caries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Propolis is a natural product collected by bees to seal holes and repair structures in their hives. Recently it has attracted much attention as useful substance applied in medicine and cosmetics thanks to its antimicrobial properties. Contemporary dentistry is an inseparable part of medicine and therefore attempts were made to use propolis in dentistry, as well. Purpose of the study: to investigate the effect of propolis administered in chewing gum as compared to that incorporated in mouthwash on plaque accumulation, microbial population and patient acceptance.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Propolis and Their Active Constituents for Chronic Diseases.
Chavda VP, Chaudhari AZ, Teli D, Balar P, et al · · 2023 · cited 18× · PMID 36830794 · DOI 10.3390/biomedicines11020259

Verify or expand the search:

Other recruiting trials for Early Childhood Caries

Currently open trials in the same condition.

NCT05761197 — Oropharyngeal Candidiasis (OPC) and S-ECC · recruiting
NCT06441500 — Oral Health and Dental Caries Prevention Intervention for Children in Romania · NA · recruiting
NCT06241261 — Arresting Early Childhood Caries With a Silver Diamine Fluoride Gel · Phase 2 · active not recruiting
NCT05716867 — Salivary Cystatin S Levels in a Group of Egyptian Children · active not recruiting

Other Nourhan M.Aly trials

Trials by the same sponsor.

NCT06763419 — Internal Photobiomodulation For Management Of Temporomandibular Joint Internal Derangement · NA · recruiting
NCT06146296 — THE EFFECT OF VITAMIN C ON POST-ORTHODONTIC TREATMENT RELAPSE · Phase 2, PHASE3 · unknown
NCT05811728 — Three-dimensional Assessment of the Bone Changes Accompanying Laser-assisted Orthodontic Tooth Movement · NA · completed
NCT06352658 — Efficacy of Different Treatments for Obstructive Sleep Apnea · NA · completed
NCT05782088 — Single Versus Repeated Piezocision-assisted Orthodontic Tooth Movement · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03812315 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Nourhan M.Aly
Last refreshed: 25 February 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03812315.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing