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NCT03812120
L-PRF in Cranial Surgery
NA trial testing Dural closure with L-PRF in Cranial Sutures; Closure in 350 participants. Status unknown.
31 December 2022
Quick facts
| Lead sponsor | Universitaire Ziekenhuizen KU Leuven |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 350 |
| Start date | 1 December 2018 |
| Primary completion | 31 December 2022 |
| Estimated completion | 31 December 2023 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Dural closure with L-PRF
- Dural closure with classical fibrin sealants
Conditions studied
- Cranial Sutures; Closure — all drugs for Cranial Sutures; Closure →
Sponsor
Universitaire Ziekenhuizen KU Leuven — full company profile →
Who can join
18 and older, any sex, with Cranial Sutures; Closure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators want to demonstrate in a prospective, randomized trial including 350 patients undergoing cranial surgery that the use of L-PRF is non-inferior to classical fibrin sealants.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Leukocyte- and platelet-rich fibrin in cranial surgery: a single-blinded, prospective, randomized controlled noninferiority trial.
Coucke B, De Vleeschouwer S, van Loon J, Van Calenbergh F, et al · · 2024 · cited 3× · PMID 38394657 · DOI 10.3171/2023.12.jns232125 -
Leukocyte- and platelet-rich fibrin in cranial surgery: study protocol for a prospective, parallel-group, single-blinded randomized controlled non-inferiority trial {1}.
Coucke B, Van Hoylandt A, van Loon J, Van Calenbergh F, et al · · 2023 · cited 1× · PMID 36959672 · DOI 10.1186/s13063-023-07252-w
Verify or expand the search:
- PubMed search for NCT03812120
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03812120 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitaire Ziekenhuizen KU Leuven
- Last refreshed: 22 January 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03812120.
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