NCT03811769: LASTE

Large Stroke Therapy Evaluation

Terminated NA Last updated 29 September 2025

What this trial tests

NA trial testing Best Medical Therapy in Stroke in 335 participants. Terminated before completion.

Timeline

7 April 2019

Primary endpoint
26 April 2023

24 August 2023

Quick facts

Lead sponsor	University Hospital, Montpellier
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	335
Start date	7 April 2019
Primary completion	26 April 2023
Estimated completion	24 August 2023
Sites	1 location across France

Drugs / interventions tested

• Best Medical Therapy — full drug profile →
• Mechanical Thrombectomy — full drug profile →

Conditions studied

• Stroke — all drugs for Stroke →

Sponsor

University Hospital, Montpellier

Who can join

18 and older, any sex, with Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Stroke represents the fourth leading cause of death in industrialized nations, after heart disease, cancer, and chronic lower respiratory disease. The overall burden of stroke will rise dramatically in the next 20 years due to an ageing population. Approximately one-quarter of the patients suffering a stroke die within one year after the initial event and stroke is a leading cause of serious long-term disability. Acute ischemic stroke (AIS) due to large vessel occlusion (LVO) is a potentially devastating event, with a poor prognosis in the absence of timely revascularization. Whether in patients with large anterior circulation stroke, direct mechanical intervention is equally effective, superior or inferior to bridging thrombolysis remains a matter of debate.

Thus, this procedure, is now the recommended standard of care for selective patients with LVO in the anterior circulation. When performed with newer generation devices (mainly stent retrievers), more stringent imaging selection criteria and more efficient workflow than in previous trials, significantly reduces disability rates after AIS caused by LVO in the anterior circulation.

The STAIR (Stroke Treatment Academic Industry Roundtable) meeting aims to advance acute stroke therapy development through collaboration between academia, industry, and regulatory institutions. In pursuit of this goal and building on the available level I evidence of benefit from endovascular therapy (EVT) in large vessel occlusion stroke, STAIR IX consensus recommendations were developed that outline priorities for future research in EVT.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size.
   Costalat V, Jovin TG, Albucher JF, Cognard C, et al · · 2024 · cited 203× · PMID 38718358 · DOI 10.1056/nejmoa2314063
2. Mechanical Thrombectomy for Large Ischemic Stroke: A Systematic Review and Meta-analysis.
   Li Q, Abdalkader M, Siegler JE, Yaghi S, et al · · 2023 · cited 89× · PMID 37277200 · DOI 10.1212/wnl.0000000000207536
3. Acute ischaemic stroke: recent advances in reperfusion treatment.
   Widimsky P, Snyder K, Sulzenko J, Hopkins LN, et al · · 2023 · cited 82× · PMID 36477996 · DOI 10.1093/eurheartj/ehac684
4. Intracranial Hemorrhage After Reperfusion Therapies in Acute Ischemic Stroke Patients.
   Maïer B, Desilles JP, Mazighi M. · · 2020 · cited 64× · PMID 33362701 · DOI 10.3389/fneur.2020.599908
5. Cerebral Edema in Patients With Large Hemispheric Infarct Undergoing Reperfusion Treatment: A HERMES Meta-Analysis.
   Ng FC, Yassi N, Sharma G, Brown SB, et al · · 2021 · cited 62× · PMID 34384229 · DOI 10.1161/strokeaha.120.033246
6. Evaluation of acute mechanical revascularization in large stroke (ASPECTS ⩽5) and large vessel occlusion within 7 h of last-seen-well: The LASTE multicenter, randomized, clinical trial protocol.
   Costalat V, Lapergue B, Albucher JF, Labreuche J, et al · · 2024 · cited 54× · PMID 37462028 · DOI 10.1177/17474930231191033
7. Outcomes of Mechanical Thrombectomy for Patients With Stroke Presenting With Low Alberta Stroke Program Early Computed Tomography Score in the Early and Extended Window.
   Almallouhi E, Al Kasab S, Hubbard Z, Bass EC, et al · · 2021 · cited 53× · PMID 34878550 · DOI 10.1001/jamanetworkopen.2021.37708
8. Multivariable Prediction Model for Futile Recanalization Therapies in Patients With Acute Ischemic Stroke.
   Meinel TR, Lerch C, Fischer U, Beyeler M, et al · · 2022 · cited 47× · PMID 35803722 · DOI 10.1212/wnl.0000000000200815