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IV Ketorolac on Platelet Function Post-Cesarean Delivery (KetoPltAgg)
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption. The effect of NSAIDs on healthy volunteers results in inhibition of platelet aggregation and prolonged bleeding time. However, in the obstetric population, the presence and degree of platelet inhibition after NSAID exposure is less clear. The investigators plan to use Platelet Aggregometry and Thromboelastography (TEG) to evaluate the effect of ketorolac on platelets.
Details
| Lead sponsor | Beth Israel Deaconess Medical Center |
|---|---|
| Phase | PHASE4 |
| Status | COMPLETED |
| Enrolment | 40 |
| Start date | Mon Jan 18 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sat Mar 30 2024 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Analgesia, Obstetrical
- Coagulation Defect; Postpartum
- Nonsteroidals (NSAIDs)Toxicity
- Postpartum Hemorrhage
- Postoperative Pain
- Ketorolac Adverse Reaction
- Blood Loss, Postoperative
Interventions
- Ketorolac Tromethamine 30 MG/ML
- Placebos
Countries
United States