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NCT03802383
The Relationship Between Trans-diaphragmatic Pressure and Diaphragmatic Contraction
trial in Weaning Failure in 30 participants. Status unknown.
30 June 2024
Quick facts
| Lead sponsor | University of Thessaly |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 29 June 2018 |
| Primary completion | 30 June 2024 |
| Estimated completion | 30 June 2024 |
| Sites | 1 location across Greece |
Conditions studied
- Weaning Failure — all drugs for Weaning Failure →
- Respiratory Paralysis — all drugs for Respiratory Paralysis →
- Respiratory Failure — all drugs for Respiratory Failure →
Sponsor
University of Thessaly
Who can join
18 and older, any sex, with Weaning Failure or Respiratory Paralysis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Through this study the investigators aim to clarify the relationship between trans-diaphragmatic pressure and various parameters of the diaphragmatic contraction evaluated by ultrasound. Moreover, a lung ultrasound exam will be performed at the end of spontaneous breathing, resistive breathing and maximal inspiratory pressure maneuver (MIP) in order to assess with the use of B-lines for extravascular lung water (EVLW). The following parameters will be studied: esophageal pressure, gastric pressure, diaphragm thickness at peak inspiration (Tdi,pi), diaphragm thickness at end expiration (Tdi,ee), diaphragm thickening (Tdi,pi - Tdi,ee), diaphragm thickness fraction \[TFdi=(Tdi,pi - Tdi,ee)/Tdi,ee\], diaphragm excursion (Dec), Maximal Inspiratory pressure (M.I.P), Pressure-Time product of the esophageal pressure (PΤPes),Tension Time Diaphragm Index (T.T.Di) and the rapid shallow breathing index (R.S.B.I.). These measurements will be made in two phases.Firstly, during the spontaneous breathing trial and secondly during spontaneous breathing through an airway of reduced diameter.Furthermore, during the M.I.P. test the aforementioned ultrasound parameters will be measured. The aim of this study is to discover new means of a successful prediction of weaning in the first 48 hours following extubation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Diaphragmatic ultrasound and its relationship to breathing effort and load: a prospective observational study.
Menis AA, Tsolaki V, Papadonta ME, Vazgiourakis V, et al · · 2025 · PMID 40361191 · DOI 10.1186/s13054-025-05436-1
Verify or expand the search:
- PubMed search for NCT03802383
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03802383 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Thessaly
- Last refreshed: 26 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03802383.
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