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NCT03800914: HIIT in fILD
High Intensity Interval Training in Fibrotic Interstitial Lung Disease
NA trial testing High intensity interval training in Fibrotic Interstitial Lung Disease in 131 participants. Completed in 4 December 2024.
4 April 2024
Quick facts
| Lead sponsor | Monash University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 131 |
| Start date | 17 July 2019 |
| Primary completion | 4 April 2024 |
| Estimated completion | 4 December 2024 |
| Sites | 4 locations across Australia |
Drugs / interventions tested
- High intensity interval training
- Traditional pulmonary rehabilitation
Conditions studied
- Fibrotic Interstitial Lung Disease — all drugs for Fibrotic Interstitial Lung Disease →
Sponsor
Monash University
Who can join
18 and older, any sex, with Fibrotic Interstitial Lung Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The fibrotic interstitial lung diseases (fILD) is a group of debilitating chronic lung conditions that are characterised by scarring of lung tissue, dyspnoea on exertion and significant physical impairment. Exercise training is recommended for people with fILD in improving breathlessness and exercise tolerance. However, despite the best efforts of patients and clinicians, many of those who participate are not attaining its benefits. The current exercise training strategies of moderate intensity continuous training may not be well suited to fILD. High intensity interval training (HIIT), short bouts of high-intensity exercise regularly interspersed with periods of rest or light exercise may be an alternate exercise training option for people with fILD. The study will determine to whether HIIT is better than the current method of continuous exercise training at moderate intensity in improving exercise tolerance, breathlessness and quality of life in people with fILD. A randomised controlled, assessor blinded trial will be conducted. A total 130 people with fILD will be randomly assigned to moderate intensity continuous training or HIIT. If this trial demonstrates that HIIT is effective, it will provide an exercise training strategy that can readily be implemented in practice that will maximise the outcomes of exercise training for people with fILD.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
High intensity interval training versus moderate intensity continuous training for people with interstitial lung disease: protocol for a randomised controlled trial.
Dowman LM, May AK, Hill CJ, Bondarenko J, et al · · 2021 · cited 5× · PMID 34758808 · DOI 10.1186/s12890-021-01704-2 -
The Rationale, Evidence, and Adaptations to Pulmonary Rehabilitation for Chronic Respiratory Diseases Other Than COPD.
Evans RA. · · 2024 · cited 3× · PMID 38806225 · DOI 10.4187/respcare.12089 -
Non-Pharmacological Management of Idiopathic Pulmonary Fibrosis.
Mullholand JB, Grossman CE, Perelas A. · · 2025 · cited 1× · PMID 40004847 · DOI 10.3390/jcm14041317
Verify or expand the search:
- PubMed search for NCT03800914
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of High intensity interval training
Trials testing the same drug.
- NCT07153523 — Effect of High Intensity Interval Training on Strength, Endurance and Flexibility · NA · recruiting
- NCT07328568 — Effect of Low Volume Sprint Interval Training on Cardiorespiratory Fitness · NA · active not recruiting
- NCT07025694 — Exercise Training Among Children With Cerebral Palsy to Increase Health and Well-being - A Feasibility Study · NA · recruiting
- NCT06509464 — Response Of Metabolic Syndrome Severity Score To High Intenisty Interval Training In Women With Central Obesity. · NA · recruiting
- NCT07046520 — Effects of HIIT on Plasma Volume and Aerobic Capacity in Obese Adolescent Girls · NA · completed
Other recruiting trials for Fibrotic Interstitial Lung Disease
Currently open trials in the same condition.
- NCT07482917 — Optimizing the Diagnostic Journey in Interstitial Lung Disease: The OPTIMIZE-ILD-1 Trial · NA · recruiting
- NCT07486206 — Optimizing the Follow-Up Journey in Interstitial Lung Disease: The OPTIMIZE-ILD-2 Trial · NA · recruiting
- NCT06053164 — Ambulatory Oxygen Therapy for Individuals With Mild-to-moderate Interstitial Lung Disease · Phase 2 · recruiting
Other Monash University trials
Trials by the same sponsor.
- NCT07428473 — A Study of STX-1150 in Participants With Elevated Low-Density Lipoprotein Cholesterol (LDL-C) · Phase 1 · not yet recruiting
- NCT07300254 — Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis: · recruiting
- NCT06960967 — Effects of Chestnuts on Postprandial Glycaemic Response · NA · active not recruiting
- NCT07202078 — Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Starting Immunoglobulin (Start Ig) · Phase 2, PHASE3 · recruiting
- NCT07202091 — Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Immunoglobulin Stopping or Extension (Stop Ig) · Phase 2, PHASE3 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03800914 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Monash University
- Last refreshed: 8 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03800914.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing