NCT03800875 (Dual) is a Phase 2 clinical trial of 27-hour inpatient intervention in Diabetes Mellitus, Type 1, sponsored by McGill University.

Who is sponsoring NCT03800875?

NCT03800875 is sponsored by McGill University.

What drugs are being tested in NCT03800875?

Interventions in NCT03800875: 27-hour inpatient intervention.

What condition does NCT03800875 study?

NCT03800875 studies Diabetes Mellitus, Type 1.

Is NCT03800875 still recruiting?

NCT03800875 is currently completed. Last updated 8 June 2021.

Last reviewed 2021-06-08 · How we verify

NCT03800875: Dual

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Insulin-plus-pramlintide Closed-loop Strategy to Regulate Glucose Levels Without Carbohydrate Counting

Completed Phase 2 Last updated 8 June 2021

What this trial tests

Phase 2 trial testing 27-hour inpatient intervention in Diabetes Mellitus, Type 1 in 24 participants. Completed in 19 September 2020.

Timeline

8 February 2019

Primary endpoint
19 September 2020

19 September 2020

Quick facts

Lead sponsor	McGill University
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	treatment
Enrollment	24
Start date	8 February 2019
Primary completion	19 September 2020
Estimated completion	19 September 2020
Sites	1 location across Canada

Drugs / interventions tested

27-hour inpatient intervention — full drug profile →

Conditions studied

Diabetes Mellitus, Type 1 — all drugs for Diabetes Mellitus, Type 1 →

Sponsor

McGill University

Who can join

18 and older, any sex, with Diabetes Mellitus, Type 1. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Closed-loop system systems that are shown to alleviate the burden of carbohydrate counting without degrading glucose control are still lacking. In this proposal, the investigators aim to develop a novel, fully-automated, closed-loop system that delivers insulin and pramlintide that controls postprandial glucose levels without any input from the user.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

A fully artificial pancreas versus a hybrid artificial pancreas for type 1 diabetes: a single-centre, open-label, randomised controlled, crossover, non-inferiority trial.
Tsoukas MA, Majdpour D, Yale JF, Fathi AE, et al · · 2021 · cited 35× · PMID 34580055 · DOI 10.1016/s2589-7500(21)00139-4
Pharmacologic treatment options for type 1 diabetes: what's new?
Nally LM, Sherr JL, Van Name MA, Patel AD, et al · · 2019 · cited 13× · PMID 30892094 · DOI 10.1080/17512433.2019.1597705
56<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes : 21-25 September 2020.
· 2020 · cited 9× · PMID 32840677 · DOI 10.1007/s00125-020-05221-5
Where Do We Stand with Closed-Loop Systems and Their Challenges?
Jackson M, Castle JR. · · 2020 · cited 4× · PMID 32069100 · DOI 10.1089/dia.2019.0469

Verify or expand the search:

Other recruiting trials for Diabetes Mellitus, Type 1

Currently open trials in the same condition.

NCT07325461 — Feasibility Study of Extended Wear Insulin Infusion Set Options During Home Use in People With Type 1 Diabetes · NA · recruiting
NCT07305805 — A Research Study of a New Medicine NNC0363-1063 in Participants With Type 1 Diabetes · Phase 1 · recruiting
NCT06282055 — Trajectories in Insulin Sensitivity Across MEnstrual cycleS in Women With Type 1 Diabetes · recruiting
NCT06325202 — Closed Loop and Education for Hypoglycemia Awareness Restoration · NA · recruiting
NCT07160816 — A Research Study to See How Insulin Icodec Helps People With Type 1 Diabetes Control Their Blood Sugar · recruiting

Other McGill University trials

Trials by the same sponsor.

NCT07178535 — Feasibility of Real-Time Visual Feedback in Augmented Reality to Reduce Gait Asymmetry Post-Stroke · NA · not yet recruiting
NCT07445841 — Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training · NA · recruiting
NCT07447830 — The Pain Reduction Using Immersive Virtual Reality During Wound Care Evaluation Study at Maimonides (PRISM) - Pilot Stud · NA · recruiting
NCT07497425 — Neuroimmune Responses to Exercise in Chronic Back Pain · NA · recruiting
NCT06994559 — Music as an Adjunct to Ketamine Therapy for Chronic Pain · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03800875 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by McGill University
Last refreshed: 8 June 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03800875.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing